Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells

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RECERCAT Home > Universitat de Barcelona > Química Inorgànica i Orgànica > Articles publicats en revistes (Química Inorgànica i Orgànica) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/110712

dc.contributor	Universitat de Barcelona
dc.contributor.author	Gandioso, Albert
dc.contributor.author	Massaguer i Vall-llovera, Anna
dc.contributor.author	Villegas, Núria
dc.contributor.author	Salvans, Cándida
dc.contributor.author	Sánchez, Dani
dc.contributor.author	Brun-Heath, Isabelle
dc.contributor.author	Marchán Sancho, Vicente
dc.contributor.author	Orozco López, Modesto
dc.contributor.author	Terrazas Martínez, Montserrat
dc.date	2017-05-09T13:25:52Z
dc.date	2018-12-31T06:10:19Z
dc.date	2017-02-13
dc.date	2017-05-09T13:25:52Z
dc.identifier.citation	1359-7345
dc.identifier.citation	667552
dc.identifier.uri	http://hdl.handle.net/2445/110712
dc.format	4 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Royal Society of Chemistry
dc.relation	Versió postprint del document publicat a: https://doi.org/10.1039/C6CC10287E
dc.relation	Chemical Communications, 2017, vol. 53, num. 19, p. 2870-2873
dc.relation	https://doi.org/10.1039/C6CC10287E
dc.rights	(c) Gandioso et al., 2017
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	RNA
dc.subject	Pèptids
dc.subject	Càncer de mama
dc.subject	Cèl·lules canceroses
dc.subject	RNA
dc.subject	Peptides
dc.subject	Breast cancer
dc.subject	Cancer cells
dc.title	Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides remains still a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different size and complexity. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines.

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