Título:
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Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells
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Autor/a:
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Gandioso, Albert; Massaguer i Vall-llovera, Anna; Villegas, Núria; Salvans, Cándida; Sánchez, Dani; Brun-Heath, Isabelle; Marchán Sancho, Vicente; Orozco López, Modesto; Terrazas Martínez, Montserrat
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Otros autores:
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Universitat de Barcelona |
Abstract:
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Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides remains still a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different size and complexity. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines. |
Materia(s):
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-RNA -Pèptids -Càncer de mama -Cèl·lules canceroses -RNA -Peptides -Breast cancer -Cancer cells |
Derechos:
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(c) Gandioso et al., 2017
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Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Royal Society of Chemistry
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Compartir:
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