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Títol:	Enantioselective total synthesis of fluvirucinin B1
Autor/a:	Guignard, Guillaume; Llor Brunés, Núria; Molins i Grau, Elies; Bosch Cartes, Joan; Amat Tusón, Mercedes
Altres autors:	Universitat de Barcelona
Abstract:	A convergent synthesis of fluvirucinin B1 from acid ent-6a and nitrile ent-9, involving an organocopper coupling, a stereoselective allylation, a ring-closing metathesis reaction, and a stereoselective hydrogenation as the key steps, is reported. The starting building blocks have been prepared in a straightforward manner from a common phenylglycinol-derived lactam 1. An unprecedented regioselective oxidation of phenylglycinol-derived secondary amines 5 to carboxylic acids 6 has been developed.
Matèries:	-Síntesi orgànica -Lactames -Organic synthesis -Lactams
Drets:	(c) American Chemical Society , 2016
Tipus de document:	Article Article - Versió acceptada
Publicat per:	American Chemical Society
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