dc.contributor.author |
Lao, Joan R. |
dc.contributor.author |
Fernández-Pérez, Hector |
dc.contributor.author |
Vidal-Ferran, Anton |
dc.date.accessioned |
2018-01-15T16:04:57Z |
dc.date.accessioned |
2018-02-15T10:28:29Z |
dc.date.available |
2018-01-15T16:04:57Z |
dc.date.available |
2018-02-15T10:28:29Z |
dc.date.issued |
2015 |
dc.identifier.uri |
http://hdl.handle.net/2072/226407 |
dc.identifier.uri |
http://hdl.handle.net/2072/305852 |
dc.language.iso |
eng |
dc.publisher |
American Chemical Society |
dc.relation |
Ministerio de Economía y Competitividad |
dc.relation |
ICIQ Foundation |
dc.relation |
Proyectos de I+D |
dc.relation |
Severo Ochoa Excellence Accreditation 2014-2018 |
dc.relation |
MORECAT |
dc.relation.ispartof |
Org. Lett. |
dc.rights |
© 2015 American Chemical Society |
dc.title |
Hydrogenative Kinetic Resolution of Vinyl Sulfoxides |
dc.type |
info:eu-repo/semantics/article |
dc.relation.projectID |
CTQ2014-60256-P |
dc.relation.projectID |
SEV-2013-0319 |
dc.identifier.doi |
https://dx.doi.org/10.1021/acs.orglett.5b02139 |
dc.rights.accessLevel |
info:eu-repo/semantics/openAccess |
dc.description.abstract |
Enantiopure sulfoxides are valuable precursors of organosulfur compounds with a broad application in organic and pharmaceutical chemistry. An unprecedented strategy for obtaining highly enantioenriched sulfoxides based on a hydrogenative kinetic resolution using Rh-complexes of phosphine-phosphites ligands as catalysts is reported. After optimization, highly efficient conditions for the kinetic resolution of racemic sulfoxides have been identified. This methodology has been applied to a set of racemic aralkyl or aryl vinyl sulfoxides and allowed the isolation of both recovered and reduced product in excellent yields and enantioselectivities (up to 99% and 97% ee, respectively; 16 examples). |