dc.contributor.author |
Echavarren, Antonio M. |
dc.contributor.author |
Dorel, Ruth |
dc.date.accessioned |
2018-06-15T11:36:18Z |
dc.date.available |
2018-06-15T11:36:18Z |
dc.date.created |
2015 |
dc.date.issued |
2015-06-10 |
dc.identifier.uri |
http://hdl.handle.net/2072/326396 |
dc.format.extent |
7321 p. |
dc.language.iso |
eng |
dc.publisher |
J. Org. Chem. |
dc.rights |
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source |
RECERCAT (Dipòsit de la Recerca de Catalunya) |
dc.subject.other |
Quimica |
dc.title |
Gold-Catalyzed Reactions via Cyclopropyl Gold Carbene-like Intermediates |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/draft |
dc.subject.udc |
54 - Química |
dc.embargo.terms |
cap |
dc.relation.projectID |
321066 |
dc.identifier.doi |
0.1021/acs.joc.5b01106 |
dc.rights.accessLevel |
info:eu-repo/semantics/openAccess |
dc.description.abstract |
Cycloisomerizations of 1,n-enynes catalyzed by gold(I) proceed via electrophilic species with a highly distorted cyclopropyl gold(I) carbene-like structure, which can react with different nucleophiles to form a wide variety of products by attack at the cyclopropane or the carbene carbons. Particularly important are reactions in which the gold(I) carbene reacts with alkenes to form cyclopropanes either intra- or intermolecularly. In the absence of nucleophiles, 1,n-enynes lead to a variety of cycloisomerized products including those resulting from skeletal rearrangements. Reactions proceeding through cyclopropyl gold(I) carbene-like intermediates are ideally suited for the bioinspired synthesis of terpenoid natural products by the selective activation of the alkyne in highly functionalized enynes or polyenynes. |