Metal-Free Synthesis of N-Aryl Amides using Organocatalytic Ring-Opening Aminolysis of Lactones

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Use this identifier to quote or link this document: http://hdl.handle.net/2072/356181

Title:	Metal-Free Synthesis of N-Aryl Amides using Organocatalytic Ring-Opening Aminolysis of Lactones
Author:	Guo, Wusheng; Gómez, José Enrique; Martínez-Rodríguez, Luis; Bandeira, Nuno A. G.; Bo, Carles; Kleij, Arjan W.
Abstract:	Catalytic ring-opening of bio-sourced non-strained lactones with aromatic amines can offer a straightforward, 100% atom- economical and sustainable pathway towards relevant N-aryl amide scaffolds. We herein report the first general, metal-free and highly efficient N-aryl amide formation from poorly reactive aromatic amines and non-strained lactones under mild operating conditions using an organic bicyclic guanidine catalyst. This protocol has great application potential as exemplified by the formal syntheses of drug relevant molecules.
Publication date:	2017-05-09
Subject(s):	54
Rights:	L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/
Pages:	1969 p.
Document type:	Article Article - Accepted version
DOI:	10.1002/cssc.201700415
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