Título:
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A site isolation-enabled organocatalytic approach to enantiopure -amino alcohol drugs
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Autor/a:
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Wang, Shoulei; Rodríguez-Escrich, Carles; Fan, Xinyuan; Pericàs, Miquel A.
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Abstract:
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Solid support-enabled site isolation has previously allowed to use paraldehyde as an acetaldehyde surrogate in aldol reactions. However, only electron-poor aldehydes were tolerated by the system. Herein, we show that the temporary conversion of benzaldehyde into η6-benzaldehyde Cr(CO)3 circumvents this limitation. Asymmetric synthesis of (R)-Phenoperidine, as well as formal syntheses of (R)-Fluoxetine and (R)-Atomoxetine, illustrate the benefits of this strategy. |
Fecha de creación:
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19-07-2018 |
Materia(s):
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54 |
Derechos:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Páginas:
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3943 p. |
Tipo de documento:
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Artículo Artículo - Versión aceptada |
DOI:
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10.1016/j.tet.2018.04.022
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