dc.contributor.author |
Wang, Shoulei |
dc.contributor.author |
Rodríguez-Escrich, Carles |
dc.contributor.author |
Fan, Xinyuan |
dc.contributor.author |
Pericàs, Miquel A. |
dc.date.accessioned |
2020-05-08T08:19:55Z |
dc.date.available |
2020-05-08T08:19:55Z |
dc.date.issued |
2018-07-19 |
dc.identifier.uri |
http://hdl.handle.net/2072/374851 |
dc.format.extent |
3943 p. |
dc.language.iso |
eng |
dc.rights |
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source |
RECERCAT (Dipòsit de la Recerca de Catalunya) |
dc.subject.other |
54 |
dc.title |
A site isolation-enabled organocatalytic approach to enantiopure -amino alcohol drugs |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.embargo.terms |
12 mesos |
dc.relation.projectID |
MINECO (CTQ2015-69136-R) |
dc.identifier.doi |
10.1016/j.tet.2018.04.022 |
dc.rights.accessLevel |
info:eu-repo/semantics/openAccess |
dc.description.abstract |
Solid support-enabled site isolation has previously allowed to use paraldehyde as an acetaldehyde surrogate in aldol reactions. However, only electron-poor aldehydes were tolerated by the system. Herein, we show that the temporary conversion of benzaldehyde into η6-benzaldehyde Cr(CO)3 circumvents this limitation. Asymmetric synthesis of (R)-Phenoperidine, as well as formal syntheses of (R)-Fluoxetine and (R)-Atomoxetine, illustrate the benefits of this strategy. |