dc.contributor.author |
Vara González, Covadonga |
dc.contributor.author |
Paytuví-Gallart, Andreu |
dc.contributor.author |
Cuartero, Yasmina |
dc.contributor.author |
Le Dily, François |
dc.contributor.author |
García, Francisca |
dc.contributor.author |
Salvà Castro, Judith |
dc.contributor.author |
Gomez Hernández, Laura |
dc.contributor.author |
Julià, Eva |
dc.contributor.author |
Moutinho, Catia |
dc.contributor.author |
Aiese Cigliano, Riccardo |
dc.contributor.author |
Sanseverino, Walter |
dc.contributor.author |
Fornas, Òscar |
dc.contributor.author |
Martín Pendas, Alberto |
dc.contributor.author |
Heyn, Holger |
dc.contributor.author |
Waters, Paul D. |
dc.contributor.author |
Martí Renom, Marc A. |
dc.contributor.author |
Ruiz-Herrera Moreno, Aurora |
dc.date |
2019 |
dc.identifier |
https://ddd.uab.cat/record/223523 |
dc.identifier |
urn:10.1016/j.celrep.2019.06.037 |
dc.identifier |
urn:oai:ddd.uab.cat:223523 |
dc.identifier |
urn:pmid:31291573 |
dc.identifier |
urn:scopus_id:85067969386 |
dc.identifier |
urn:articleid:22111247v28n2p352 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/fc87a185-045b-46d1-ab80-3ed5f5f23479 |
dc.identifier |
urn:pmc-uid:6635386 |
dc.identifier |
urn:pmcid:PMC6635386 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6635386 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
European Commission 676556 |
dc.relation |
European Commission 609989 |
dc.relation |
Ministerio de Economía y Competitividad BFU2017-89408-R |
dc.relation |
Ministerio de Economía y Competitividad BFU2017-85926-P |
dc.relation |
Ministerio de Economía y Competitividad CGL2017-83802-P |
dc.relation |
Ministerio de Economía y Competitividad SAF2017-89109-P |
dc.relation |
Ministerio de Economía y Competitividad BES-2015-072924 |
dc.relation |
Ministerio de Economía y Competitividad BFU2015-71786-REDT |
dc.relation |
Ministerio de Economía y Competitividad CGL2014-54317-P |
dc.relation |
Ministerio de Economía y Competitividad BFU2013-47736-P |
dc.relation |
Ministerio de Economía y Competitividad SEV-2012-0208 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca DI2015 |
dc.relation |
Cell reports ; Vol. 28, issue 2 (Jul. 2019), p. 352-367 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.title |
Three-dimensional genomic structure and cohesin occupancy correlate with transcriptional activity during spermatogenesis |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: Agaur SGR468 to M.A.M-R. A.P.-G. is supported by a 'Doctorats Industrials' predoctoral fellowship (AGAUR). H.H. is a Miguel Servet (CP14/00229) researcher funded by the Spanish Institute of Health Carlos III (ISCIII) |
dc.description.abstract |
Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis by combining in situ chromosome conformation capture sequencing (Hi-C), RNA sequencing (RNA-seq), and chromatin immunoprecipitation sequencing (ChIP-seq) of CCCTC-binding factor (CTCF) and meiotic cohesins, coupled with confocal and super-resolution microscopy. Spermatogonia presents well-defined compartment patterns and topological domains. However, chromosome occupancy and compartmentalization are highly re-arranged during prophase I, with cohesins bound to active promoters in DNA loops out of the chromosomal axes. Compartment patterns re-emerge in round spermatids, where cohesin occupancy correlates with transcriptional activity of key developmental genes. The compact sperm genome contains compartments with actively transcribed genes but no fine-scale topological domains, concomitant with the presence of protamines. Overall, we demonstrate how genome-wide cohesin occupancy and transcriptional activity is associated with three-dimensional (3D) remodeling during spermatogenesis, ultimately reprogramming the genome for the next generation. |