dc.contributor.author |
Guirado Frias, Pedro León |
dc.contributor.author |
Paytubi Casabona, Sònia |
dc.contributor.author |
Miró, Elisenda |
dc.contributor.author |
Iglesias Torrens, Yaidelys |
dc.contributor.author |
Navarro Risueño, Ferran |
dc.contributor.author |
Cerdà-Cuéllar, Marta |
dc.contributor.author |
Stephan-Otto Attolini, Camille |
dc.contributor.author |
Balsalobre Parra, Carlos |
dc.contributor.author |
Madrid Xufré, Cristina |
dc.date |
2020 |
dc.identifier |
https://ddd.uab.cat/record/252478 |
dc.identifier |
urn:10.3390/microorganisms8030325 |
dc.identifier |
urn:oai:ddd.uab.cat:252478 |
dc.identifier |
urn:pmcid:PMC7142995 |
dc.identifier |
urn:pmc-uid:7142995 |
dc.identifier |
urn:pmid:32110976 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:7142995 |
dc.identifier |
urn:articleid:20762607v8n3p325 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Agencia Estatal de Investigación PGC2018-096958-B-I00 |
dc.relation |
Ministerio de Economía y Competitividad AGL2013-45339R |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-499 |
dc.relation |
Microorganisms ; Vol. 8, issue 3 (March 2020), art. 325 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Campylobacter |
dc.subject |
Lipooligosaccharide |
dc.subject |
Wlan |
dc.subject |
Cgtb |
dc.subject |
Guillain-Barré syndrome |
dc.title |
Differential distribution of the wlaN and cgtB genes, associated with Guillain-Barré syndrome, in Campylobacter jejuni isolates from humans, broiler chickens, and wild birds |
dc.type |
Article |
dc.description.abstract |
Campylobacter jejuni causes campylobacteriosis, a bacterial gastroenteritis with high incidence worldwide. Moreover, C. jejuni infection can trigger the polyneuropathic disorder denominated Guillain-Barré syndrome (GBS). The C. jejuni strains that can elicit GBS carry either wlaN or cgtB, coding both genes for a β-1,3-galactosyltransferase enzyme that is required for the production of sialylated lipooligosaccharide (LOS SIAL). We described a differential prevalence of the genes wlaN and cgtB in C. jejuni isolates from three different ecological niches: humans, broiler chickens, and wild birds. The distribution of both genes, which is similar between broiler chicken and human isolates and distinct when compared to the wild bird isolates, suggests a host-dependent distribution. Moreover, the prevalence of the wlaN and cgtB genes seems to be restricted to some clonal complexes. Gene sequencing identified the presence of new variants of the G- homopolymeric tract within the wlaN gene. Furthermore, we detected two variants of a G rich region within the cgtB gene, suggesting that, similarly to wlaN, the G-tract in the cgtB gene mediates the phase variation control of cgtB expression. Caco-2 cell invasion assays indicate that there is no evident correlation between the production of LOS SIAL and the ability to invade eukaryotic cells. |