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Postoperative pain in patients with opioid tolerance: the importance of therapeutic individualisation 

Jiménez Carrascal, Ivan (Fecha de publicación: 2025-10)

Background: patients with chronic cancer pain are often treated with opioids for pain relief. However, their exposure leads to tolerance and alterations in the nociceptive signal, requiring increased doses to achieve the ...

Improving post-discharge care in infective endocarditis patients not undergoing otherwise indicated cardiac surgery: protocol for a multicenter randomized clinical trial to evaluate mortality and sex- and age-related differences 

Tarradas Juncà, Rafel (Fecha de publicación: 2025-10)

BACKGROUND: Infective endocarditis is associated with high morbidity and mortality, especially among patients with a surgical indication who do not undergo cardiac surgery (SINUS-IE). After hospital discharge, these patients ...

On the relevance of query definition in the performance of 3D ligand-based virtual screening 

Vázquez Lozano, Javier; Garcia, Ricardo; Linares, Paula; Luque Garriga, F. Xavier; Herrero, Enric (Fecha de publicación: 2026-03-27)

Ligand-based virtual screening (LBVS) methods are widely used to explore the vast chemical space in the search of novel compounds resorting to a variety of properties encoded in 1D, 2D or 3D descriptors. The success of ...

Clinical Characteristics and Surgical Outcomes of Patients Receiving Perioperative Pembrolizumab in KEYNOTE-671 

Liberman, Moishe; R. Jones, David; Wakelee, Heather; Gao, Shugeng; Halmos, Balazs; Nadal, Ernest; Łowczak, Anna; Reck, Martin; Novello, Silvia; Matias, Danielli; Luft, Alexander; Hui, Rina; Lee, Se-hoon; Tsuboi, Masahiro; Kato, Terufumi; Zhu, Yuming; Weksler, Benny; Jensen, Erin; Samkari, Ayman; M. Keller, Steven; D. Spicer, Jonathan (Fecha de publicación: 2026-03-27)

BACKGROUND The phase 3 KEYNOTE-671 study (NCT03425643) demonstrated significantly improved event-free survival (EFS) and overall survival with neoadjuvant pembrolizumab plus chemotherapy followed by surgery and adjuvant ...

Biocompatible 3D printed yttria-stabilized zirconia parts using direct ink writing 

Buj Corral, Irene; Sanz Fraile, Héctor; Tejo-Otero, Aitor; Vidal, Daniel; Padilla Sanchez, Jose Antonio; Xuriguera Martín, María Elena; Otero Diaz, Jorge (Fecha de publicación: 2026-03-27)

Metals such as titanium or Cr-Co alloys have been the most widely used materials in biomedical applications that requirehigh mechanical properties, like implants. However, these materials present the disadvantage of releasing ...