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Título:
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Oxidative stress in bacteria and protein damage by reactive oxygen species
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Autor/a:
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Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim
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Notas:
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The advent of O2 in the atmosphere was among the first major pollution
events occurred on earth. The reaction between ferrous iron, very abundant in the
reductive early atmosphere, and oxygen results in the formation of harmful superoxide
and hydroxyl radicals, which affect all macromolecules (DNA, lipids and proteins).
Living organisms have to build up mechanisms to protect themselves against oxidative
stress, with enzymes such as catalase and superoxide dismutase, small proteins like
thioredoxin and glutaredoxin, and molecules such as glutathione. Bacterial genetic
responses to oxidative stress are controlled by two major transcriptional regulators
(OxyR and SoxRS). This paper reviews major key points in the generation of reactive
oxygen species in bacteria, defense mechanisms and genetic responses to oxidative
stress. Special attention is paid to the oxidative damage to proteins.
Some research work described in this review was supported in part by Grant PB94-0829-C02-02 from DGICYT of the Spanish Government, and by the Comissionat per Universitats i Recerca of the Autonomous Government of Catalonia. |
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Materia(s):
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-Oxygen
-Oxidative stress
-Reactive oxygen species
-Protein oxidation |
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Derechos:
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(c) Spanish Society for Microbiology, Springer-Verlag Ibérica, 2000
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Tipo de documento:
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article
publishedVersion |
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Editor:
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Springer-Verlag Ibérica
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Compartir:
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