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Títol:
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Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver
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Autor/a:
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Ayala Jové, Ma. Victoria (Maria Victoria); Naudí i Farré, Alba; Sanz, Alberto; Caro, Pilar; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald
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Notes:
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Caloric restriction (CR) decreases oxidative damage, which contributes to the slowing of aging
rate. It is not known if such decreases are due to calories themselves or specific dietary components.
In this work, the ingestion of proteins of Wistar rats was decreased by 40% below that
of controls. After 7 weeks, the liver of the protein-restricted (PR) animals showed decreases in
oxidative protein damage, degree of membrane unsaturation, and mitochondrial complex I
content. The results and previous information suggest that the decrease in the rate of aging
induced by PR can be due in part to decreases in mitochondrial reactive oxygen species
production and DNA and protein oxidative modification, increases in fatty acid components more
resistant to oxidative damage, and decreased expression of complex I, analogously to what occurs
during CR. Recent studies suggest that those benefits of PR could be caused, in turn, by the
lowered methionine intake of that dietary manipulation
This study was supported in part by IþD grants from the Spanish Ministry of Education and Science (BFU2006-14495/BFI), the Generalitat of Catalunya (2005SGR00101), ‘‘La Marato TV3’’ Foundation, ‘‘La Caixa’’ Foundation, and the Spanish Ministry of Health to R.P. and M.P.O.; and from the Spanish Ministry of Science and Technology (SAF2002- 01635) and the Ministry of Education and Science (BFU2005-02584) to G.B. |
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Drets:
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(c) The Gerontological Society of America, 2007
info:eu-repo/semantics/restrictedAccess |
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Tipus de document:
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article
publishedVersion |
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Publicat per:
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Oxford University Press
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