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Títol:
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Specific anti-Neospora caninum IgG1 and IgG2 antibody responses during gestation in naturally infected cattle and their relationship with gamma interferon production
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Autor/a:
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Almería, S.; Nogareda, Carmina; Santolaria Blasco, Pilar; García Ispierto, Irina; Yániz Pérez de Albéniz, Jesús; López Gatius, Fernando
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Notes:
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Gamma interferon (IFN-g) production has been attributed a protective role against
abortion in Neospora-infected dairy cows. This study investigate possible relationships
between plasma levels of the N. caninum-specific immunoglobulin (Ig) isotypes IgG1 and
IgG2 and IFN-g production throughout gestation in dairy cows naturally infected with the
parasite. Data were obtained from 31 pregnant Neospora-seropositive animals. Blood
samples were collected on gestation days 40, 90, 120, 150, 180 and 210 or until abortion.
Ten pregnancies ended in abortion. One of the 11 cows producing IFN-g suffered abortion
(9.1% of the cows producing IFN-g). Non-aborting cows producing IFN-g (n = 10) showed a
significantly higher IgG2/IgG1 antibody ratio throughout the gestation period than cows
not producing IFN-g (n = 11). A significant negative effect of IFN-g production on IgG1
antibodies was also observed, while IFN-g production did not affect IgG2 antibody levels.
In contrast, higher levels of IgG2 antibodies compared to IgG1 antibodies were observed
over the whole of gestation in aborting animals, both in those not producing IFN-g and in
the single aborting cow that produced the cytokine. Our findings indicate that a Th1
immune response, in which IgG2 antibodies prevail, could be protective against N.
caninum abortion, but only in the presence of IFN-g production. On their own, elevated
IgG2 antibody titres appear to be insufficient to protect dams chronically infected with N.
caninum against abortion.
This work was supported by the Spanish CICYT, grants AGL2007-65521-C02-01/GAN and AGL2007-65521-C02-02/GAN. |
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Matèries:
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-Neospora caninum
-IgG1 antibodies
-IgG2 antibodies
-IFN-gamma |
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Drets:
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(c) Elsevier B.V., 2009
info:eu-repo/semantics/restrictedAccess |
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Tipus de document:
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article
publishedVersion |
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Publicat per:
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Elsevier
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Compartir:
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