|
Título:
|
Genetic Marker Discovery in Complex Traits: A Field Example on Fat Content and Composition in Pigs
|
|
Autor/a:
|
Pena i Subirà, Ramona Natacha; Ros Freixedes, Roger; Tor i Naudí, Marc; Estany Illa, Joan
|
|
Notas:
|
Among the large number of attributes that define pork quality, fat content and composition
have attracted the attention of breeders in the recent years due to their interaction with human health
and technological and sensorial properties of meat. In livestock species, fat accumulates in different
depots following a temporal pattern that is also recognized in humans. Intramuscular fat deposition
rate and fatty acid composition change with life. Despite indication that it might be possible to
select for intramuscular fat without affecting other fat depots, to date only one depot-specific genetic
marker (PCK1 c.2456C>A) has been reported. In contrast, identification of polymorphisms related
to fat composition has been more successful. For instance, our group has described a variant in the
stearoyl-coA desaturase (SCD) gene that improves the desaturation index of fat without affecting
overall fatness or growth. Identification of mutations in candidate genes can be a tedious and costly
process. Genome-wide association studies can help in narrowing down the number of candidate
genes by highlighting those which contribute most to the genetic variation of the trait. Results from
our group and others indicate that fat content and composition are highly polygenic and that very
few genes explain more than 5% of the variance of the trait. Moreover, as the complexity of the
genome emerges, the role of non-coding genes and regulatory elements cannot be disregarded.
Prediction of breeding values from genomic data is discussed in comparison with conventional best
linear predictors of breeding values. An example based on real data is given, and the implications
in phenotype prediction are discussed in detail. The benefits and limitations of using large SNP
sets versus a few very informative markers as predictors of genetic merit of breeding candidates are
evaluated using field data as an example.
Research partially funded by the Spanish Ministry of Economy and Competitiveness and the European Union Regional Development Funds (AGL2015-65846-R). |
|
Materia(s):
|
-Meat quality
-Intramuscular fat
-Candidate gene
-Pork
-Oleic acid
-Monounsaturated fatty acid |
|
Derechos:
|
cc-by (c) Estany Illa, Joan., et al. 2016
http://creativecommons.org/licenses/by/3.0/es/
|
|
Tipo de documento:
|
article
publishedVersion |
|
Editor:
|
MDPI
|
|
Compartir:
|
|
