|
Título:
|
A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma
|
|
Autor/a:
|
Servià Goixart, Lluís; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier
|
|
Notas:
|
Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients.
Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established by liquid chromatography coupled to mass spectrometry, in patients allocated to an intensive care unit (in the University Hospital Arnau de Vilanova, Lleida, Spain) in the first hours after a severe trauma (n = 48). Univariate and multivariate statistics were employed to establish potential predictors of mortality.
Results: Plasma of patients non surviving to trauma (n = 5) exhibited a discriminating metabolomic pattern, involving basically metabolites belonging to fatty acid and catecholamine synthesis as well as tryptophan degradation pathways. Thus, concentration of several metabolites exhibited an area under the receiver operating curve (ROC) higher than 0.84, including 3-indolelactic acid, hydroxyisovaleric acid, phenylethanolamine, cortisol, epinephrine and myristic acid. Multivariate binary regression logistic revealed that patients with higher myristic acid concentrations had a non-survival odds ratio of 2.1 (CI 95% 1.1–3.9).
Conclusions: Specific fatty acids, catecholamine synthesis and tryptophan degradation pathways could be implicated in a negative outcome after trauma. The metabolomic study of severe trauma patients could be helpful for biomarker proposal.
This work has been partially supported by the IRBLleida biobank and RETICS BIOBANCOS RD09/0076/00059, the Spanish Ministry of Economy and Competitiveness, Institute of Health Carlos III (PI 17–00134) and the Generalitat of Catalonia (2017SGR969). FEDER Funds are also acknowledged: “A way to make Europe”. MJ is a professor under the Serra Hunter program (Generalitat de Catalunya). |
|
Materia(s):
|
-Metabolome
-Mortality
-Traumatic brain injury
-Biomarker
-Multiple traumatism |
|
Derechos:
|
cc-by (c) Servià et al., 2019
http://creativecommons.org/licenses/by/4.0/
|
|
Tipo de documento:
|
Artículo
Artículo - Versión publicada |
|
Editor:
|
BMC (part of Springer Nature)
|
|
Compartir:
|
|
