Manifold learning visualization of metabotropic glutamate receptors

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Título:	Manifold learning visualization of metabotropic glutamate receptors
Autor/a:	Cárdenas Domínguez, Martha Ivón; Vellido Alcacena, Alfredo; Giraldo Arjonilla, Jesús
Otros autores:	Universitat Politècnica de Catalunya. Departament de Ciències de la Computació; Universitat Politècnica de Catalunya. SOCO - Soft Computing
Abstract:	G-Protein-Coupled Receptors (GPCRs) are cell membrane proteins with a key role in biological processes. GPCRs of class C, in particular, are of great interest in pharmacology. The lack of knowledge about their 3-D structures means they must be investigated through their primary amino acid sequences. Sequence visualization can help to explore the existing receptor sub-groupings at different partition levels. In this paper, we focus on Metabotropic Glutamate Receptors (mGluR), a subtype of class C GPCRs. Different versions of a probabilistic manifold learning model are employed to comparatively sub-group and visualize them through different transformations of their sequences.
Abstract:	Peer Reviewed
Materia(s):	-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica -Protein research -G-protein-coupled receptors -Metabotropic glutamate receptors -Data visualization -Generative topographic mapping -Proteïnes -- Investigació
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Tipo de documento:	Artículo - Versión presentada Objeto de conferencia
Editor:	IOS Press
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Cárdenas Domínguez, Martha Ivón; Vellido Alcacena, Alfredo; König, Caroline; Alquézar Mancho, René; Giraldo Arjonilla, Jesús

Cárdenas Domínguez, Martha Ivón; Vellido Alcacena, Alfredo; König, Caroline; Alquézar Mancho, René; Giraldo Arjonilla, Jesús

Cárdenas Domínguez, Martha Ivón; Vellido Alcacena, Alfredo; Giraldo Arjonilla, Jesús

König, Caroline; Alquézar Mancho, René; Vellido Alcacena, Alfredo; Giraldo Arjonilla, Jesús

König, Caroline; Alquézar Mancho, René; Vellido Alcacena, Alfredo; Giraldo Arjonilla, Jesús

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