The aim of this project is the optimization of an Eco-industrial park through innovative methodologies. I have been working in a chemical laboratory, performing a stage, in order to support a PhD student’s thesis. Most of the time I have been working with computer simulations and some of the information obtained are not shown in this report. Additionally, my work has been based on writing an article, what is presented in this report, to explain the methodology used for the design of an Eco-Industrial park, as well as the case study. As you will see, the article is not completed and some parts have been eliminated. This parts are those related to the optimization process, where the PhD student is working and is not finished yet. For that reason, it is better not to not present some results that may be wrong or incomplete. Anyway, in some months, this article will be completed and published.