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Títol:	Multifunctional ZnO NPs-chitosan-gallic acid hybrid nanocoating to overcome contact lenses associated conditions and discomfort
Autor/a:	Hoyo Pérez, Javier; Ivanova, Kristina Dimitrova; Guaus Guerrero, Ester; Tzanov, Tzanko
Altres autors:	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
Abstract:	Contact lenses (CL) provide visual correction but their use may also induce several adverse effects causative of discomfort and conditions that lead to stop or discontinue their use. Discomfort is mainly caused by insufficient wetting, impairment of the antioxidant defence system and eye infections. The current work reports on a single step sonochemical coating of CL with ZnO nanoparticles (NPs), chitosan (CS) and gallic acid (GA). GA and CS are expected to improve the comfort of CL by imparting respectively antioxidant properties and enhanced wettability, while their combination with ZnO NPs provides the CL with antimicrobial properties. The ternary composite coating presents high antibacterial efficiency (> 4.5 logs reduction) against S. aureus causative of CL-related conditions, and maintains good biocompatibility (> 72 %) with human cell lines. The obtained multi-functionality on the CL did not affect their geometry and refractive properties.
Abstract:	Peer Reviewed
Matèries:	-Àrees temàtiques de la UPC::Enginyeria química -Chitosan -Contact lenses -ZnO nanoparticles -chitosan -gallic acid -sonochemistry -antibacterial coating -Quitosan
Drets:	Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Tipus de document:	Article - Versió presentada Article
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