Working life has come to permeate every domain of life. Characteristics once thought to affect only the job domain have become important determinants of how people assess their daily lives. This article explores the influence of job characteristics on satisfaction with several life domains in 28 EU countries, asking: 1) What is the relationship between job characteristics and satisfaction with work and other domains of life? 2) Is the job domain more important for life satisfaction than other domains of life? Additionally, we apply a domains-of-life perspective to investigate possible differences in these relationships between high- and low-skilled workers, using data on white-collar workers from the third European Quality of Life Survey (3EQLS) and multiple Ordinary Least Squares (OLS) regressions to estimate the models. Work-life balance and perceived job (in)security emerge as important determinants of satisfaction regarding all domains and both types of workers studied. Satisfaction in the work domain ranks fourth in contributing to overall life satisfaction, after the standard of living, family life and social life domains. This relatively low direct contribution to life satisfaction of the work domain is particularly visible among low-skilled workers. We conclude with a discussion of the implications for workers' wellbeing of the increasing insecurity in the job market and the fact that meaning is often sought through work despite the effects of poor work-life balance on most life-domains.