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Title:
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Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions
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Author:
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Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Portero Otín, Manuel; Pamplona Gras, Reinald
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Notes:
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Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes and to the pathogenesis of diabetic complications. Much evidence demonstrates the modification of aminophospholipids by glycation, glycoxidation and lipoxidation reactions. Therefore, a number of early and advanced Maillard reaction-lipid products have been detected and quantified in different biological membranes. These modifications may be accumulated during aging and diabetes, introducing changes in cell membrane physico-chemical and biological properties. |
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Subject(s):
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-Advanced glycation endproducts
-Advanced lipoxidation endproducts
-Age-associated diseases
-Aging |
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Rights:
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cc-by (c) Naudí et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
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Document type:
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article
publishedVersion |
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Published by:
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MDPI
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Share:
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