Hydroxytyrosol and its complex forms (secoiridoids) modulate aorta and heart proteome in healthy rats: Potential cardio-protective effects

Abstract

Scope Hydroxytyrosol (HT) is the major phenolic compound in virgin olive oil (VOO) in both free and complex forms (secoiridoids; SEC). Proteomics of cardiovascular tissues such as aorta or heart represents a promising tool to uncover the mechanisms of action of phenolic compounds in healthy animals.

Ú.C., L.R., M.-C.L., M.-J.M., and R.S. conceived and designed the experiments. M.-C.L. conducted the experiments. Ú.C., M.-C.L., and L.R. acquired the data. P.H., P.N., and N.C. processed the samples. Ú.C. and L.R. analyzed and interpreted the data. Ú.C., L.R., and P.H. drafted the article. Ú.C., L.R., M.-C.L., M.-J.M., and R.S. revising the article critically for important intellectual content. This study was supported by the Spanish Ministry of Education and Science, The MEFOPC Project (AGL2012-40144-C03-03 and AGL2012-40144-C03-02) and by the University of Lleida through the M-C. López de las Hazas grant.