| dc.contributor.author |
Son, Maren van |
| dc.contributor.author |
Gjerlaug Enger, Eli |
| dc.contributor.author |
Grove, Harald |
| dc.contributor.author |
Ros Freixedes, Roger |
| dc.contributor.author |
Kent, Matthew P. |
| dc.contributor.author |
Lien, Sigbjørn |
| dc.contributor.author |
Grindflek, Eli |
| dc.date |
2017-05-29T09:29:20Z |
| dc.date |
2017-05-29T09:29:20Z |
| dc.date |
2017 |
| dc.identifier |
1471-2164 |
| dc.identifier |
http://hdl.handle.net/10459.1/59723 |
| dc.identifier |
https://doi.org/10.1186/s12864-017-3752-0 |
| dc.identifier.uri |
http://hdl.handle.net/10459.1/59723 |
| dc.description |
Background: Fatty acid composition contributes importantly to meat quality and is essential to the nutritional
value of the meat. Identification of genetic factors underlying levels of fatty acids can be used to breed for pigs
with healthier meat. The aim of this study was to conduct genome-wide association studies (GWAS) to identify QTL
regions affecting fatty acid composition in backfat from the pig breeds Duroc and Landrace.
Results: Using data from the Axiom porcine 660 K array, we performed GWAS on 454 Duroc and 659 Landrace
boars for fatty acid phenotypes measured by near-infrared spectroscopy (NIRS) technology (C16:0, C16:1n-7, C18:0,
C18:1n-9, C18:2n-6, C18:3n-3, total saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty
acids). Two QTL regions on SSC4 and SSC14 were identified in Duroc for the de novo synthesized fatty acids traits,
whereas one QTL on SSC8 was detected in Landrace for C16:1n-7. The QTL region on SSC14 has been reported in
previous studies and a putative causative mutation has been suggested in the promoter region of the SCD gene.
Whole genome re-sequencing data was used for genotype imputation and to fine map the SSC14 QTL region in
Norwegian Duroc. This effort confirms the location of the QTL on this chromosome as well as suggesting other
putative candidate genes in the region. The most significant single nucleotide polymorphisms (SNPs) located on
SSC14 explain between 55 and 76% of the genetic variance and between 27 and 54% of the phenotypic variance
for the de novo synthesized fatty acid traits in Norwegian Duroc. For the QTL region on SSC8 in Landrace, the most
significant SNP explained 19% of the genetic variance and 5% of the phenotypic variance for C16:1n-7.
Conclusions: This study confirms a major QTL affecting fatty acid composition on SSC14 in Duroc, which can be
used in genetic selection to increase the level of fatty acid desaturation. The SSC14 QTL was not segregating in the
Landrace population, but another QTL on SSC8 affecting C16:1n-7 was identified and might be used to increase the
level of desaturation in meat products from this breed. |
| dc.language |
eng |
| dc.publisher |
BioMed Central |
| dc.relation |
Reproducció del document publicat a https://doi.org/10.1186/s12864-017-3752-0 |
| dc.relation |
BMC Genomics, 2017, vol. 18, núm. 369, p. 1-13 |
| dc.rights |
cc-by (c) Son et al., 2017 |
| dc.rights |
http://creativecommons.org/licenses/by/4.0/ |
| dc.rights |
info:eu-repo/semantics/openAccess |
| dc.subject |
GWAS |
| dc.subject |
QTL mapping |
| dc.subject |
Fine mapping |
| dc.subject |
Pigs |
| dc.subject |
Fatty acid composition |
| dc.title |
Genome-wide association study confirm major QTL for backfat fatty acid composition on SSC14 in Duroc pigs |
| dc.type |
article |
| dc.type |
publishedVersion |
