dc.contributor.author |
Cabezón Ponsoda, Óscar |
dc.contributor.author |
Muñoz González, Sara |
dc.contributor.author |
Colom-Cadena, Andreu |
dc.contributor.author |
Rosell, Rosa |
dc.contributor.author |
Lavín González, Santiago |
dc.contributor.author |
Marco, Ignasi |
dc.contributor.author |
Fraile Sauce, Lorenzo José |
dc.contributor.author |
Martínez de la Riva, Paloma |
dc.contributor.author |
Rodríguez, Fernando |
dc.contributor.author |
Domínguez, Javier |
dc.contributor.author |
Ganges, Llilianne |
dc.date |
2017-10-17T08:47:18Z |
dc.date |
2017-10-17T08:47:18Z |
dc.date |
2017 |
dc.identifier |
1746-6148 |
dc.identifier |
https://doi.org/10.1186/s12917-017-1150-0 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/60302 |
dc.description |
Recently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. These animals also showed a type I interferon blockade in the absence of clinical signs. In this study, we assessed the infection generated in 7-week-old CSFV PI wild boars after infection with the African swine fever virus (ASFV). The wild boars were divided in two groups and were infected with ASFV. Group A comprised boars who were CSFV PI in a subclinical form and Group B comprised pestivirus-free wild boars. Some relevant parameters related to CSFV replication and the immune response of CSFV PI animals were studied. Additionally, serum soluble factors such as IFN-α, TNF-α, IL-6, IL-10, IFN-γ and sCD163 were analysed before and after ASFV infection to assess their role in disease progression. |
dc.description |
This research was supported by grants AGL2013–48998 and AGL2015–66907 from the Spanish government. S.M and A.C had |
dc.language |
eng |
dc.publisher |
BioMed Central |
dc.relation |
MINECO/PN2013-2016/AGL2013-48998 |
dc.relation |
MINECO/PN2013-2016/AGL2015-66907 |
dc.relation |
Reproducció del document publicat a https://doi.org/10.1186/s12917-017-1150-0 |
dc.relation |
BMC Veterinary Research, 2017, vol. 13, p. 227 |
dc.rights |
cc-by (c) Cabezón et al., 2017 |
dc.rights |
http://creativecommons.org/licenses/by/4.0/ |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
CSFV |
dc.subject |
CSF postnatal persistent infection |
dc.subject |
Subclinical CSF |
dc.subject |
ASFV |
dc.title |
African swine fever virus infection in Classical swine fever subclinically infected wild boars |
dc.type |
article |
dc.type |
publishedVersion |