Amyloid fibrils from organic solutions of an amphiphilic dipeptide

Abstract

Non-hydrated organic solutions of a diphenylalanine amphiphile blocked at the C-terminus with a fluorenylmethyl ester and stabilized at the N-terminus with a trifluoroacetate have been used to prepare amyloid fibrils. The solvent used to prepare the stock solution together with the co-solvent added enables regulation of the characteristics of the fibrils, which is important for their use in technological applications.

This work was supported by MINECO (RTI2018-098951-B- I00, RTI2018-101827-B-I00, and CTQ2013-40855-R), the Agència de Gestió d’Ajuts Universitaris i de Recerca (2017SGR359 and 2017SGR373) and Gobierno de Aragon-FEDER (research group Aminoacidos y Peptidos E19_17R). Support for the research of C. A. was received through the prize ‘‘ICREA Academia’’ for excellence in research funded by the Generalitat de Catalunya.