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Título:
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Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
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Autor/a:
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Casadellà, Maria; Cozzi-Lepri, Alessandro; Phillips, Andrew; Noguera-Julian, Marc; Bickel, Markus; Sedlacek, Dalibor; Zilmer, Kai; Clotet, Bonaventura; Lundgren, Jens D.; Paredes, Roger
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Otros autores:
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Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades |
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Notas:
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Objective
To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical
progression and death in routine clinical management.
Design
Nested case-control study within the EuroSIDA cohort.
Methods
Cases were subjects with AIDS or who died from any cause, with a plasma sample with
HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event.
At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were
selected per each case. Conditional logistic regression was used to investigate exposures
associated with clinical progression to AIDS or death. A linear mixed model with random
intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following
the date of sampling.
Results
The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26%
were ART-naïve. Baseline factors independently associated with clinical progression or
death were female gender (OR = 2.13 vs. male, 95CI = 1.04, 4.36), p = 0.038), CD4+T-cell
count (OR = 0.90 (95CI = 0.80, 1.00) per 100 cells/mm3 higher, p = 0.058), being on ART
(OR = 2.72 vs. being off-ART (95CI = 1.15, 6.41), p = 0.022) and calendar year of sample
[OR = 0.84 (95CI = 0.77, 0.91) per more recent year, p<0.001). Baseline tropism was not
associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ
within or between tropism groups. |
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Materia(s):
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-Sida -- Tractament
-VIH (Virus) |
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Derechos:
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Aquest document està subjecte a aquesta llicència Creative Commons
http://creativecommons.org/licenses/by/4.0/
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Tipo de documento:
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Artículo
info:eu-repo/publishedVersion |
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Editor:
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Plos One
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Compartir:
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