Sistema de Salut de Catalunya
Institut Català de la Salut
Servei d’Oncologia Radioteràpica, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2023-08-17T11:50:51Z
2023-08-17T11:50:51Z
2023-05-30
Tumor microenvironments; Head and neck cancer; Radiotherapy
Microambientes tumorales; Cáncer de cabeza y cuello; Radioterapia
Microambients tumorals; Càncer de cap i coll; Radioteràpia
Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This review highlights how the tumor microenvironment could be affected by different immune and stromal cell types, weighs the need to integrate metabolic regulation of the tumor microenvironment into cancer treatment strategies and summarizes the emerging clinical applicability of personalized immunotherapeutic strategies in HPV-negative head and neck cancer.
Article
Published version
English
Cap - Càncer - Immunoteràpia; Coll - Càncer - Immunoteràpia; DISEASES::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy; PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment; ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de cabeza y cuello; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia; FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral
OAE Publishing
Cancer Drug Resistance;6
http://dx.doi.org/10.20517/cdr.2022.141
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - HVH [3439]
