dc.contributor
Institut Català de la Salut
dc.contributor
[Channa R] Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin. [Wolf RM] Department of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland. [Simo R] Servei d’Endocrinologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERDEM, Barcelona, Spain. [Brigell M] Consultant, Belmont, Massachusetts. [Fort P] Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan. [Curcio C] Department of Ophthalmology, University of Alabama, Birmingham, Alabama
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Channa, Roomasa
dc.contributor.author
Wolf, Risa M.
dc.contributor.author
Brigell, Mitchell
dc.contributor.author
Fort, Patrice
dc.contributor.author
Curcio, Christine
dc.contributor.author
Simó Canonge, Rafael
dc.date.accessioned
2025-10-24T10:33:07Z
dc.date.available
2025-10-24T10:33:07Z
dc.date.issued
2024-02-16T14:02:31Z
dc.date.issued
2024-02-16T14:02:31Z
dc.date.issued
2023-10-31
dc.identifier
Channa R, Wolf RM, Simo R, Brigell M, Fort P, Curcio C, et al. A New Approach to Staging Diabetic Eye Disease: Staging of Diabetic Retinal Neurodegeneration and Diabetic Macular Edema. Ophthalmol Sci. 2023 Oct 31;4(3):100420.
dc.identifier
https://hdl.handle.net/11351/11063
dc.identifier
10.1016/j.xops.2023.100420
dc.identifier
001154911200001
dc.identifier.uri
https://hdl.handle.net/11351/11063
dc.description.abstract
Biomarkers; Diabetic retinal disease; Neuro-retinal layers
dc.description.abstract
Biomarcadores; Enfermedad de la retina diabética; Capas neurorretinianas
dc.description.abstract
Biomarcadors; Malaltia de la retina diabètica; Capes neurorretinàries
dc.description.abstract
Topic
The goal of this review was to summarize the current level of evidence on biomarkers to quantify diabetic retinal neurodegeneration (DRN) and diabetic macular edema (DME).
Clinical relevance
With advances in retinal diagnostics, we have more data on patients with diabetes than ever before. However, the staging system for diabetic retinal disease is still based only on color fundus photographs and we do not have clear guidelines on how to incorporate data from the relatively newer modalities into clinical practice.
Methods
In this review, we use a Delphi process with experts to identify the most promising modalities to identify DRN and DME. These included microperimetry, full-field flash electroretinogram, spectral-domain OCT, adaptive optics, and OCT angiography. We then used a previously published method of determining the evidence level to complete detailed evidence grids for each modality.
Results
Our results showed that among the modalities evaluated, the level of evidence to quantify DRN and DME was highest for OCT (level 1) and lowest for adaptive optics (level 4).
Conclusion
For most of the modalities evaluated, prospective studies are needed to elucidate their role in the management and outcomes of diabetic retinal diseases.
dc.format
application/pdf
dc.relation
Ophthalmology Science;4(3)
dc.relation
https://doi.org/10.1016/j.xops.2023.100420
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Marcadors bioquímics
dc.subject
Retinopatia diabètica
dc.subject
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
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DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Angiopathies::Diabetic Retinopathy
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DISEASES::Eye Diseases::Retinal Diseases::Retinal Degeneration::Macular Degeneration::Macular Edema
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
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ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::angiopatías diabéticas::retinopatía diabética
dc.subject
ENFERMEDADES::oftalmopatías::enfermedades de la retina::degeneración retiniana::degeneración macular::edema macular
dc.title
A New Approach to Staging Diabetic Eye Disease: Staging of Diabetic Retinal Neurodegeneration and Diabetic Macular Edema
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
