Sistema de Salut de Catalunya
Institut Català de la Salut
[Coloretti I, Genovese A] Anesthesia and Intensive Care Medicine, Policlinico Di Modena, University of Modena and Reggio Emilia, Italy. [Teixeira JP] Divisions of Nephrology and Pulmonary, Critical Care, and Sleep Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA. [Cherian A] Anesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Dhanvantri Nagar, Pondicherry, India. [Ferrer R] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Landoni G] Anesthesia and Intensive Care, IRCCS San Rafaele Scientifc Institute, Milan, Italy
Vall d'Hebron Barcelona Hospital Campus
2024-02-26T12:42:51Z
2024-02-26T12:42:51Z
2024-02-21
Angiotensina II; Shock sèptic; Vasopressors
Angiotensin II; Septic shock; Vasopressors
Angiotensina II; Shock séptico; Vasopresores
Patients with septic shock who experience refractory hypotension despite adequate fluid resuscitation and high-dose noradrenaline have high mortality rates. To improve outcomes, evidence-based guidelines recommend starting a second vasopressor, such as vasopressin, if noradrenaline doses exceed 0.5 µg/kg/min. Recently, promising results have been observed in treating refractory hypotension with angiotensin II, which has been shown to increase mean arterial pressure and has been associated with improved outcomes. This narrative review aims to provide an overview of the pathophysiology of the renin-angiotensin system and the role of endogenous angiotensin II in vasodilatory shock with a focus on how angiotensin II treatment impacts clinical outcomes and on identifying the population that may benefit most from its use.
Article
Published version
English
Xoc sèptic - Tractament; Hipotensió arterial; DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic; Other subheadings::Other subheadings::Other subheadings::/drug therapy; DISEASES::Cardiovascular Diseases::Vascular Diseases::Hypotension; ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis::choque séptico; Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia; ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::hipotensión
BMC
Journal of Anesthesia, Analgesia and Critical Care;4
https://doi.org/10.1186/s44158-024-00150-w
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - HVH [3440]
