Sistema de Salut de Catalunya
Institut Català de la Salut
[Llàcer P] Internal Medicine Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain. Department of Medicine and Medical Specialties, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Madrid, Spain. [Cobo Marcos M] Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Madrid, Spain. [de la Espriella R] Department of Cardiology, Hospital Clínico Universitario de Valencia, Valencia, Spain. [Gayán Ordás J] Department of Cardiology, Hospital Universitario Arnau de Vilanova, Institut de Recerca Biomèdica de Lleida, Lleida, Spain. [Zegri I] Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Fort A] Department of Cardiology, Hospital Universitari Dr Josep Trueta, Girona, Spain. [Méndez A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Soler MJ] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2024-06-10T10:40:23Z
2024-06-10T10:40:23Z
2024-05-15
Albuminuria; Cardiorenal disease; Congestion
Albuminúria; Malaltia cardiorenal; Congestió
Albuminuria; Enfermedad cardiorrenal; Congestión
Background Albuminuria could potentially emerge as a novel marker of congestion in acute heart failure. However, the current evidence linking albuminuria and congestion in patients with congestive heart failure (CHF) remains somewhat scarce. This study aimed to evaluate the prevalence of albuminuria in a cohort of patients with CHF, identify the independent factors associated with albuminuria and analyse the correlation with different congestion parameters. Methods This is a subanalysis of the Spanish Cardiorenal Registry, in which we enrolled 864 outpatients with heart failure and a value of urinary albumin:creatinine ratio (UACR) at the first visit. Results The median age was 74 years, 549 (63.5%) were male and 438 (50.7%) had a reduced left ventricular ejection fraction. A total of 350 patients (40.5%) had albuminuria. Among these patients, 386 (33.1%) had a UACR of 30–300 mg/g and 64 (7.4%) had a UACR >300 mg/g. In order of importance, the independent variables associated with higher UACR were estimated glomerular filtration rate determined by the Chronic Kidney Disease Epidemiology Collaboration equation (R2 = 57.6%), systolic blood pressure (R2 = 21.1%), previous furosemide equivalent dose (FED; R2 = 7.5%), antigen carbohydrate 125 (CA125; R2 = 6.1%), diabetes mellitus (R2 = 5.6%) and oedema (R2 = 1.9%). The combined influence of oedema, elevated CA125 levels and the FED accounted for 15.5% of the model's variability. Conclusions In patients with chronic stable heart failure, the prevalence of albuminuria is high. The risk factors of albuminuria in this population are chronic kidney disease and hypertension. Congestion parameters are also associated with increased albuminuria.
We have received funding to produce this article from Astra Zeneca.
Article
Published version
English
Insuficiència renal crònica; Insuficiència cardíaca congestiva; Albuminúria - Factors de risc; DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Urological Manifestations::Proteinuria::Albuminuria; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors; DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic; DISEASES::Cardiovascular Diseases::Heart Diseases::Heart Failure; ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::manifestaciones urológicas::proteinuria::albuminuria; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo; ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::insuficiencia renal crónica; ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::insuficiencia cardíaca
Oxford University Press
Clinical Kidney Journal;17(6)
https://doi.org/10.1093/ckj/sfae140
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - HVH [3440]
