Incidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry

Other authors

Institut Català de la Salut

[Li W] Department of Radiology, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands. [van der Doef HPJ] Division of Paediatric Gastroenterology and Hepatology, Department of Paediatrics, University Medical Centre Groningen, Groningen, The Netherlands. [Wildhaber BE] Swiss Pediatric Liver Centre, Division of Child and Adolescent Surgery, Geneva University Hospitals, Geneva, Switzerland. [Marra P] Department of Radiology, ASST Papa Giovanni XXIII, Bergamo, Italy. School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. [Bravi M] Department of Paediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy. [Pinelli D] Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy. [Quintero-Bernabeu J, Mercadal-Hally M, Larrarte K M] Servei de Cirurgia Hepatobiliopancreàtica i Trasplantaments, Vall d’Hebron Hospital Universitari, Barcelona, Spain

Vall d'Hebron Barcelona Hospital Campus

Publication date

2024-06-17T11:05:31Z

2024-06-17T11:05:31Z

2024-06-12



Abstract

Hepatology; Interventional radiology; Paediatric transplant surgery


Hepatologia; Radiologia intervencionista; Cirurgia de trasplantament pediàtric


Hepatología; Radiología intervencional; Cirugía de trasplante pediátrico


Introduction Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices and outcomes in paediatric patients with HAC after LT, including early and late complications. Methods and analysis The HEPatic Artery stenosis and Thrombosis after liver transplantation In Children (HEPATIC) Registry is an international, retrospective, multicentre, observational study. Any paediatric patient diagnosed with HAC and treated for HAC (at age <18 years) after paediatric LT within a 20-year time period will be included. The primary outcomes are graft and patient survivals. The secondary outcomes are technical success of the intervention, primary and secondary patency after HAC intervention, intraprocedural and postprocedural complications, description of current management practices, and incidence of HAC. Ethics and dissemination All participating sites will obtain local ethical approval and (waiver of) informed consent following the regulations on the conduct of observational clinical studies. The results will be disseminated through scientific presentations at conferences and through publication in peer-reviewed journals.

Document Type

Article


Published version

Language

English

Publisher

BMJ

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https://doi.org/10.1136/bmjopen-2023-081933

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Rights

Attribution-NonCommercial 4.0 International

http://creativecommons.org/licenses/by-nc/4.0/

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