Sistema de Salut de Catalunya
Arnett, Simon
Chew, Sin Hong
Leitner, Unnah
Hor, Jyh Yung
paul, friedemann
Yeaman, Michael
Arrambide, Georgina
Institut Català de la Salut
[Arnett S, Chew SH] School of Medicine and Dentistry, Gold Coast Campus, Grifth University, Gold Coast, Australia. Department of Neurology, Gold Coast University Hospital, Southport, QLD, Australia. [Leitner U] School of Medicine and Dentistry, Gold Coast Campus, Grifth University, Gold Coast, Australia. [Hor JY] Department of Neurology, Penang General Hospital, George Town, Penang, Malaysia. [Paul F] NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany. Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin, Germany. [Yeaman MR] Department of Medicine, David Gefen School of Medicine at the University of California, Los Angeles, CA, USA. Department of Medicine, Divisions of Molecular Medicine & Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA. Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. [Arrambide G] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2024-08-26T06:18:13Z
2024-08-26T06:18:13Z
2024-08
Neuromyelitis optica; Risk factors; Sex
Neuromielitis òptica; Factors de risc; Sexe
Neuromielitis óptica; Factores de riesgo; Sexo
Background Aquaporin-4 (AQP4) antibody-associated neuromyelitis optica spectrum disorder (NMOSD) is an antibody-mediated inflammatory disease of the central nervous system. We have undertaken a systematic review and meta-analysis to ascertain the sex ratio and mean age of onset for AQP4 antibody associated NMOSD. We have also explored factors that impact on these demographic data. Methods A systematic search of databases was conducted according to the PRISMA guidelines. Articles reporting sex distribution and age of onset for AQP4 antibody-associated NMSOD were reviewed. An initially inclusive approach involving exploration with regression meta-analysis was followed by an analysis of just AQP4 antibody positive cases. Results A total of 528 articles were screened to yield 89 articles covering 19,415 individuals from 88 population samples. The female:male sex ratio was significantly influenced by the proportion of AQP4 antibody positive cases in the samples studied (p < 0.001). For AQP4 antibody-positive cases the overall estimate of the sex ratio was 8.89 (95% CI 7.78–10.15). For paediatric populations the estimate was 5.68 (95% CI 4.01–8.03) and for late-onset cases, it was 5.48 (95% CI 4.10–7.33). The mean age of onset was significantly associated with the mean life expectancy of the population sampled (p < 0.001). The mean age of onset for AQP4 antibody-positive cases in long-lived populations was 41.7 years versus 33.3 years in the remainder. Conclusions The female:male sex ratio and the mean age of onset of AQP4 antibody-associated NMOSD are significantly higher than MS. The sex ratio increases with the proportion of cases that are positive for AQP4 antibodies and the mean age of onset increases with population life expectancy.
Open Access funding enabled and organized by CAUL and its Member Institutions.
English
Autoanticossos; Nervi òptic - Malalties - Diagnòstic; Sistema nerviós central - Malalties - Diagnòstic; DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Myelitis, Transverse::Neuromyelitis Optica; CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies; HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Factors::Age Factors::Age of Onset; CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Porins::Aquaporins::Aquaporin 4; PHENOMENA AND PROCESSES::Genetic Phenomena::Sex Ratio; ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::mielitis transversa::neuromielitis óptica; COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos; ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::factores epidemiológicos::factores etarios::edad de comienzo; COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas transportadoras::proteínas de transporte de membrana::canales iónicos::porinas::acuoporinas::acuaporina 4; FENÓMENOS Y PROCESOS::fenómenos genéticos::razón de sexos
Springer
Journal of Neurology;271
https://doi.org/10.1007/s00415-024-12452-8
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
