A large-scale screening of hepatitis C among men who have sex with men in the community using saliva point-of-care testing

Abstract

Hepatitis C virus; Men who have sex with men; Screening

Virus de la hepatitis C; Hombres que tienen sexo con hombres; Cribado

Virus de l'hepatitis C; Homes que tenen sexe amb homes; Cribatge

Aim: To assess the feasibility and acceptability of massive hepatitis C virus (HCV) testing in point of care on the street using quick tests, determine the characteristics of the population included, and the prevalence of HCV infection in this population. Methods: Cross-sectional community-based study including adult men who have sex with men (MSM) who attended the three most important LGTB+ events in Sitges (Catalonia, Spain) in 2022. Points of care were set up on tents on the street and attendees were offered voluntary anti-HCV antibody self-testing. Participants were informed of the study, provided consent, completed the test for identification of risk practices (TIRP), and took the test with the OraQuick® HCV test on a saliva sample (sensitivity: 97.8% [95% confidence interval (CI), 93.2-99.4%] and specificity: 100% [95% CI, 98.4-100%]; gold standard: IgG antibody test for HCV by immunoassay [serum]); participants with positive results were offered HCV virus testing with the Xpert HCV Fingerstick® on a blood drop. Results: A total of 1249 adults participated in the large-scale screening, of which 1197 (95.8%) were identified as MSM. The screening time was 39 participants/h. Four (0.32%) participants had positive anti-HCV results, all with undetectable HCV RNA levels. Participants' median (IQR) age was 44 (35, 54) years; most were Europeans, and 13% reported being unaware of their serological HCV status. The mean (SD) TIRP score was 1.40 (1.44) (n = 1062), with 67.41% reporting some risk, and the self-perceived sexually transmitted disease score was 3.0 (2.82) (n = 969). Conclusion: The point-of-care strategy on the street using a quick oral self-test at massive MSM events is feasible, well-accepted, and quick, and may be a useful strategy to reach other populations at risk of HCV infection.

T he author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This project is funded by GILEAD through a competitive research Scholarship in 2021 evaluated by the evaluation committee of the Spanish association for the study of the liver, confidentially and independent, and through a publication support. The study sponsor and funders have no role in study design; collection, management, analysis, and interpretation of data; author selection; writing of the report; and the decision to submit the report for publication.