dc.contributor
Institut Català de la Salut
dc.contributor
[Brunet-Mas E] Gastroenterlogy Department, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Sabadell, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERehd, Instituto de Salud Carlos III, Madrid, Spain. [Selva A] Clinical Epidemiology and Cancer Screening, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT_CERCA), Universitat Autònoma de Barcelona, Bellaterra, Spain. Department of Pediatrics, Obstetrics, Gynecology and Preventive Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain. [Bas-Cutrina F] Gastroenterology Department, Hospital General de Granollers, Granollers, Spain. [Brujats A] Gastroenterology Department, Hospital de Berga - Salut Catalunya Central, Berga, Spain. Gastroenterology Department, Hospital de la Santa Creu i Sant Pau de Barcelona, Barcelona, Spain. [Caballol B] Gastroenterology Department, Hospital Clinic i Provincial, Institut d'Investigacions biomèdiques Pi Sunyer (IDIBAPS), CIBEREHD, Barcelona, Spain. [Font R] Department of Health, Catalan Cancer Plan, Barcelona, Spain. Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. [Robles-Alonso V] Servei d’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Brunet, Eduard
dc.contributor.author
Selva Olid, Anna
dc.contributor.author
Bas-Cutrina, Francesc
dc.contributor.author
Caballol, Berta
dc.contributor.author
Font, Rebeca
dc.contributor.author
robles, virginia
dc.contributor.author
Brujats Rubirola, Anna
dc.date.accessioned
2025-10-24T10:25:07Z
dc.date.available
2025-10-24T10:25:07Z
dc.date.issued
2025-03-11T09:31:15Z
dc.date.issued
2025-03-11T09:31:15Z
dc.identifier
Brunet-Mas E, Selva A, Bas-Cutrina F, Brujats A, Caballol B, Font R, et al. Asymptomatic Inflammatory Bowel Disease Diagnosed During Colorectal Cancer Population Screening in Catalonia: Characteristics and Natural History. Clin Transl Gastroenterol. 2025 Feb;16(2):e00740.
dc.identifier
http://hdl.handle.net/11351/12738
dc.identifier
10.14309/ctg.0000000000000740
dc.identifier
001429041500001
dc.identifier.uri
https://hdl.handle.net/11351/12738
dc.description.abstract
Asymptomatic inflammatory bowel disease; Colorectal cancer; Population screening
dc.description.abstract
Enfermedad inflamatoria intestinal asintomática; Cribado poblacional; Cáncer colorrectal
dc.description.abstract
Malaltia inflamatòria intestinal asimptomàtica; Cribratge poblacional; Càncer colorectal
dc.description.abstract
Introduction: Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the natural history of asymptomatic IBD diagnosed through CRCSP.
Methods: An observational, longitudinal, and retrospective study was performed at 22 centers in Catalonia between January 2010 and December 2019 including patients with asymptomatic IBD detected in the CRCSP. Demographic data and IBD characteristics, evolution, and treatment were recorded. Descriptive statistics and Kaplan-Meier analysis were used for the analysis. Data were given separately for IBD, Crohn's disease (CD), ulcerative colitis (UC), and IBD unclassified (IBDU).
Results: One hundred eighty-eight patients were included: 103 UC (54.8%), 60 CD (31.9%), and 25 IBDU (13.3%). Sixty-six (35.1%) were women, and the average age was 59.9 ± 5.9 years. Sixty-four patients (34.0%) developed symptoms after a median follow-up of 35.6 months. Diarrhea was the most frequent symptom for CD and IBDU (25.4% and 11.5%, respectively) and blood in stools for UC (21.4%). The median time to first symptom was 11.6 months. Treatment was prescribed in 135 patients (72.2%); mesalazine was the most prescribed drug (123 patients; 65.4%). Thirteen patients (6.9%) required biological treatment. None underwent surgery.
Discussion: Around one-third of asymptomatic patients with IBD developed symptoms after a medium follow-up of 3 years. Only 6.9% required biological treatment, and none required surgery. Overall, prognosis of asymptomatic IBD seems better.
dc.description.abstract
This study received a 6,000€ grant for initiation to research from the Societat Catalana de Digestologia.
dc.format
application/pdf
dc.publisher
Wolters Kluwer Health
dc.relation
Clinical and Translational Gastroenterology;16(2)
dc.relation
https://doi.org/10.14309/ctg.0000000000000740
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Càncer - Detecció precoç
dc.subject
Cribatge (Medicina)
dc.subject
Intestins - Inflamació - Diagnòstic
dc.subject
Intestins - Inflamació - Prognosi
dc.subject
Còlon - Càncer - Diagnòstic
dc.subject
Recte - Càncer - Diagnòstic
dc.subject
DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases
dc.subject
Other subheadings::Other subheadings::/diagnosis
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Early Diagnosis::Early Detection of Cancer
dc.subject
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Asymptomatic Diseases
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
dc.subject
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
dc.subject
Other subheadings::Other subheadings::/diagnosis
dc.subject
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal
dc.subject
Otros calificadores::Otros calificadores::/diagnóstico
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::diagnóstico precoz::detección precoz del cáncer
dc.subject
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedades asintomáticas
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
dc.subject
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales
dc.subject
Otros calificadores::Otros calificadores::/diagnóstico
dc.title
Asymptomatic Inflammatory Bowel Disease Diagnosed During Colorectal Cancer Population Screening in Catalonia: Characteristics and Natural History
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
