Sistema de Salut de Catalunya
Institut Català de la Salut
[Dirschka T] CentroDerm Clinic, Wuppertal, Germany. [Ardigò M] Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. [Fargnoli MC] San Gallicano Dermatological Institute, IRCCS, Rome, Italy. [Ferrándiz-Pulido C] Servei de Dermatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Gilaberte Y] Department of Dermatology Miguel Servet University Hospital, University of Zaragoza, IIS Aragón, Zaragoza, Spain. [Hadshiew I] MVZ Derma Köln, Cologne, Germany
Vall d'Hebron Barcelona Hospital Campus
2025-05-26T13:14:25Z
2025-05-26T13:14:25Z
2025
Actinic keratoses; Lesion-directed treatment; Modified Delphi consensus
Queratosis actínica; Tratamiento dirigido a la lesión; Consenso Delphi modificado
Queratosis actínica; Tractament dirigit a la lesió; Consens Delphi modificat
Purpose Actinic keratosis (AK) is the main precursor of invasive cutaneous squamous cell carcinoma (cSCC). Since it is impossible to predict which lesions will progress to cSCC, early treatment of AK is crucial. Although AK treatments are effective, some are associated with local skin reactions that may impact treatment compliance and effectiveness. The aim of this modified Delphi study was to review the efficacy and safety of the different AK treatments, gain an understanding of the dermatologists’ perspectives on their use, and provide guidelines for clinical practice. Materials and methods This document corresponds to a modified Delphi consensus survey, based on a literature review and a single round of questionnaire. Results The Delphi questionnaire was completed by 73 dermatologists from Germany, Italy, and Spain. Agreement was achieved for 78% of statements, while 11% showed discrepancies or were rejected. Conclusions Key findings emphasize the importance of patient-centered approaches and treatment attributes beyond efficacy (e.g. tolerability or adherence). Understanding the mechanisms of action of treatments is vital for managing patients’ and clinicians’ expectations and optimizing outcomes. Alternative strategies for evaluating efficacy, including the Actinic Keratosis Area and Severity Index (AKASI) score and lesion reduction from baseline, were also highlighted.
This work was supported by Almirall.
Article
Published version
English
Qüestionaris; Mètode Delphi; Pell - Càncer - Tractament; Queratosi - Tractament; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires; INFORMATION SCIENCE::Information Science::Systems Analysis::Delphi Technique; DISEASES::Neoplasms::Precancerous Conditions::Keratosis, Actinic; Other subheadings::Other subheadings::/therapy; DISEASES::Neoplasms::Neoplasms by Site::Skin Neoplasms; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios; CIENCIA DE LA INFORMACIÓN::Ciencias de la información::análisis de sistemas::técnica Delfos; ENFERMEDADES::neoplasias::lesiones precancerosas::queratosis actínica; Otros calificadores::Otros calificadores::/terapia; ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias cutáneas
Taylor & Francis
https://doi.org/10.1080/09546634.2025.2487657
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
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