Sistema de Salut de Catalunya
Institut Català de la Salut
[Di Matteo B, Anzillotti G, Conte P] IRCCS Humanitas Research Hospital, Rozzano, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. [Angele P] Department of Trauma and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany. Sporthopaedicum Regensburg/Straubing, Regensburg, Germany. [Emans P] Joint Preserving Clinic, Department of Orthopedic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands. [Minguell-Monyart J] Servei de Cirurgia Ortopèdica i Traumatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
2025-05-29T06:18:17Z
2025-05-29T06:18:17Z
2025-06
Bone marrow lesions; Osteoarthritis; Subchondroplasty
Lesions de medul·la òssia; Osteoartritis; Subcondroplàstia
Lesiones de médula ósea; Osteoartritis; Subcondroplastia
Introduction. Bone marrow lesions (BMLs) are MRI-visible subchondral bone alterations, highly correlated with symptoms in the knee. Subchondroplasty (SCP) is able to fill the subchondral defects associated with BMLs using an injectable bone substitute material. The aim of the present study is to evaluate the 12-month outcomes of the SCP in the treatment of symptoms of mild-to-moderate knee osteoarthritis (OA) patients with persistent BMLs of the knee. Materials and Methods. Subjects affected by BMLs of the femoral condyle or tibial plateau that were present for >3 months and not responsive to conservative treatments were enrolled in this prospective multicenter trial. All the patients underwent SCP. Follow-up was conducted at 1, 3, 6 and 12 months. All subjects completed Numerical Rating Scale (NRS) for pain, Knee Injury and Osteoarthritis Outcome (KOOS) score, Euro Quality of life-5 dimensions (EQ-5D) score, and a subject global satisfaction scale. Demographic information of the patients was also collected. Results. A total of 79 patients completed the 12-month follow-up. Statistically significant improvements on all clinical scales were registered from baseline to the 12-month follow-up. No severe adverse events were reported. Four patients were considered failed. A 12-month subgroup analysis was performed to evaluate the possible correlation between all the KOOS subscales and age, gender, number of BMLs, location of BMLs, and Kellgren-Lawrence grade: no statistically significant associations were observed. Conclusion. SCP is a safe and effective procedure for the treatment of symptoms related to persisting BMLs in mild-to-moderate osteoarthritic knees, with a low failure rate up to 12 months’ evaluation.
The presented study was fully sponsored by Zimmer Biomet.
Article
Published version
English
Medul·la òssia - Malalties; Gonartrosi - Cirurgia; Genolls - Imatgeria per ressonància magnètica; Avaluació de resultats (Assistència sanitària); DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Bone Marrow Diseases; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging; DISEASES::Musculoskeletal Diseases::Joint Diseases::Arthritis::Osteoarthritis::Osteoarthritis, Knee; Other subheadings::Other subheadings::Other subheadings::/surgery; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome; ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::enfermedades de la médula ósea; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética; ENFERMEDADES::enfermedades musculoesqueléticas::artropatías::artritis::osteoartritis::osteoartritis de la rodilla; Otros calificadores::Otros calificadores::Otros calificadores::/cirugía; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento
SAGE Publications
CARTILAGE;16(2)
https://doi.org/10.1177/19476035241264011
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
Articles científics - HVH [3439]
