Sistema de Salut de Catalunya
Institut Català de la Salut
[Junge N] Department of Pediatric Kidney, Liver and Metabolic Diseases, Division for Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany. European Reference Network TransplantChild, Madrid, Spain. European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee, Geneva, Switzerland. [Karam V] The European Society for Organ Transplantation, Amsterdam, The Netherlands. [Hartog H] Department of Surgery, Section of Hepatobiliary Surgery & Liver Transplantation, University Medical Centre Groningen, Groningen, The Netherlands. European Liver and Intestine Transplant Association Board, Padova, Italy. [Adam R] The European Society for Organ Transplantation, Amsterdam, The Netherlands. European Liver and Intestine Transplant Association Board, Padova, Italy. Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation AP‐HP Hôpital Paul Brousse, Université Paris‐Saclay, Villejuif, France. [Cailliez V] The European Society for Organ Transplantation, Amsterdam, The Netherlands. Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation AP‐HP Hôpital Paul Brousse, Université Paris‐Saclay, Villejuif, France. [Indolfi G] European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee, Geneva, Switzerland. Meyer Children's Hospital IRCCS, Florence, Italy. [Quintero J] European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) Hepatology Committee, Geneva, Switzerland. Servei de Gastroenterologia, Hepatologia, Suport Nutricional i Trasplantaments Hepàtics Pediàtrics, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2025-07-08T07:59:01Z
2025-07-08T07:59:01Z
2025-07
Graft survival; Living‐donor liver transplantation; Patient survival
Supervivencia del injerto; Trasplante de hígado de donante vivo; Supervivencia del paciente
Supervivència de l'empelt; Trasplantament de fetge de donant viu; Supervivència del pacient
Objectives The European Liver Transplant Registry (ELTR) has been collecting data on liver transplantation (LT) in Europe since 1968. The aim of this report is to outline the number, techniques utilized, indications for, and outcomes of pediatric LT (pLT) in Europe, focusing on the Year 2022 in comparison to the preceding 5 years. Methods Data were obtained from ELTR and Eurotransplant (ET). Summary statistics were performed. Results In 2022, 585 pLTs were performed in Europe. The annual number of pLT decreased for the third consecutive year. Living donor LT represented 34% (n = 201) of pLT. The proportion of living donation (LD) remained stable over time. The major indication for pLT in Europe is biliary atresia. Donor age is increasing overall and is associated with worse graft survival. Graft and patient survival were impacted by both types of donors and types of grafts, and were significantly worse after re-transplantation. Most graft failures (77%) and deaths (82%) occurred within the first 6 months after pLT. Conclusion Annual numbers of pLT in Europe are decreasing over time. Given that the proportion of LD has remained stable, the shortage of deceased donor organs may not be the major reason for this trend, and other factors play a role. A focus on improving perioperative care is needed because the risk of graft loss and mortality is highest in the first 6 months after transplantation. New techniques like ex-situ machine perfusion may help mitigate risks with declining quality of deceased donor liver grafts.
Article
Published version
English
Fetge - Trasplantació; Infants; Avaluació de resultats (Assistència sanitària); Donants d'òrgans; Empelt contra l'hoste, Malaltia de l'; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Digestive System Surgical Procedures::Surgical Procedures, Operative::Surgical Procedures, Operative::Liver Transplantation; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome; NAMED GROUPS::Persons::Tissue Donors::Living Donors; PHENOMENA AND PROCESSES::Immune System Phenomena::Transplantation Immunology::Host vs Graft Reaction::Graft Survival; NAMED GROUPS::Persons::Age Groups::Child; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos del sistema digestivo::intervenciones quirúrgicas::intervenciones quirúrgicas::trasplante de hígado; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento; DENOMINACIONES DE GRUPOS::personas::donantes de tejidos::donantes vivos; FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunología del trasplante::reacción huésped contra injerto::supervivencia del injerto; DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño
Wiley
Journal of Pediatric Gastroenterology and Nutrition;81(1)
https://doi.org/10.1002/jpn3.70065
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - HVH [3440]
