SEOM-GEMCAD-TTD clinical guidelines for biliary tract cancer (2025)

Other authors

Institut Català de la Salut

[Macarulla T] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Adeva J] Medical Oncology Department, Hospital Universitario, 12 de Octubre, Madrid, Spain. [Cano Osuna MT] Medical Oncology Department, Hospital Universitario Reina Sofía, Córdoba, Spain. [Ruiz Casado A] Medical Oncology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. [Jiménez Gordo AM] Medical Oncology Department, Hospital Universitario Infanta Sofía, Madrid, Spain. [Lamarca A] Medical Oncology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain

Vall d'Hebron Barcelona Hospital Campus

Publication date

2025-08-12T11:45:12Z

2025-08-12T11:45:12Z

2025-08



Abstract

Biliary tract cancer; Diagnosis; Precision medicine


Cáncer del tracto biliar; Diagnóstico; Medicina de precisión


Càncer del tracte biliar; Diagnòstic; Medicina de precisió


Biliary tract cancers (BTC) are aggressive and fatal. Early recognition of symptoms and proper diagnostic work up allow for precise histopathological and molecular classification as well as accurate evaluation of the extent of disease. Surgery is the only potentially curative therapy in localized stages; however, disease recurrence is common and adjuvant chemotherapy appears to improve survival. Upfront systemic chemotherapy with immunotherapy is the treatment of choice in unresectable locally-advanced and metastatic disease. Inroads made in understanding its molecular biology has enabled new therapeutic targets to be identified with current indications and encouraging results that could further improve BTC patients' survival and quality of life.

Document Type

Article


Published version

Language

English

Publisher

Springer

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Attribution-NonCommercial-NoDerivatives 4.0 International

http://creativecommons.org/licenses/by-nc-nd/4.0/

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