dc.contributor
Institut Català de la Salut
dc.contributor
[Buongiorno M] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Tur C] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Giraldo DM] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Cullell N] Fundació per a Docència i Recerca, Mútua Terrassa, Terrassa, Spain. [Krupinski J] Fundació per a Docència i Recerca, Mútua Terrassa, Terrassa, Spain. Department of Neurology, Fundació Assistencial Mútua Terrassa, Terrassa, Spain. Faculty of Science and Engineering, Department of Life Sciences, Manchester Metropolitan University, Manchester, UK. [Lanzillo R] Multiple Sclerosis Clinical Care and Research Centre, Federico II University Hospital of Naples, Naples, Italy. Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
KRUPINSKI, JERZY
dc.contributor.author
Lanzillo, Roberta
dc.contributor.author
Buongiorno, Mariateresa
dc.contributor.author
TUR, CARMEN
dc.contributor.author
Giraldo, Darly M.
dc.contributor.author
Cullell, Natalia
dc.date.accessioned
2025-10-24T08:50:36Z
dc.date.available
2025-10-24T08:50:36Z
dc.date.issued
2025-10-06T10:29:55Z
dc.date.issued
2025-10-06T10:29:55Z
dc.identifier
Buongiorno M, Tur C, Giraldo DM, Cullell N, Krupinski J, Lanzillo R, et al. Sleep and Risk of Multiple Sclerosis: Bridging the Gap Between Inflammation and Neurodegeneration via Glymphatic Failure. Brain Sci. 2025 Jul;15(7):766.
dc.identifier
http://hdl.handle.net/11351/13789
dc.identifier
10.3390/brainsci15070766
dc.identifier
001535391600001
dc.identifier.uri
https://hdl.handle.net/11351/13789
dc.description.abstract
Multiple sclerosis; Neurodegeneration; Sleep
dc.description.abstract
Esclerosis múltiple; Neurodegeneración; Dormir
dc.description.abstract
Esclerosi múltiple; Neurodegeneració; Dormir
dc.description.abstract
Epidemiological studies identified insufficient and poor-quality sleep as independent risk factors for multiple sclerosis (MS). The glymphatic system, active during slow-wave sleep, clears brain waste through perivascular astrocytic aquaporin-4 (AQP4) channels. The presence of antigens induces a transient, physiological lowering of glymphatic flux as a first step of an inflammatory response. A possible hypothesis linking infection with the Epstein-Barr virus, a well identified causal step in MS, and the development of the disease is that mechanisms such as poor sleep or less functional AQP4 polymorphisms may sustain glymphatic flow reduction. Such chronic glymphatic reduction would trigger a vicious circle in which the persistence of antigens and an inflammatory response maintains glymphatic dysfunction. In addition, viral proteins that persist in demyelinated plaques can depolarize AQP4, further restricting waste elimination and sustaining local inflammation. This review examines the epidemiological evidence connecting sleep and MS risk, and the mechanistic findings showing how poor sleep and other glymphatic modulators heighten inflammatory signaling implicated in MS pathogenesis. Deepening knowledge of glymphatic functioning in MS could open new avenues for personalized prevention and therapy.
dc.description.abstract
GS-B receives support from grant CP23/00039, funded by the Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union/FSE+ and the MCIN/AEI/10.13039/501100011033, through project PID2020-119556RA-I00.
dc.format
application/pdf
dc.relation
Brain Sciences;15(7)
dc.relation
https://doi.org/10.3390/brainsci15070766
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Esclerosi múltiple - Factors de risc
dc.subject
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
dc.subject
PHENOMENA AND PROCESSES::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Sleep
dc.subject
ANATOMY::Nervous System::Central Nervous System::Brain::Glymphatic System
dc.subject
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo
dc.subject
FENÓMENOS Y PROCESOS::fenómenos fisiológicos nerviosos y musculoesqueléticos::fenómenos fisiológicos del sistema nervioso::sueño
dc.subject
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo::sistema glinfático
dc.subject
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación
dc.title
Sleep and Risk of Multiple Sclerosis: Bridging the Gap Between Inflammation and Neurodegeneration via Glymphatic Failure
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
