Sistema de Salut de Catalunya
Institut Català de la Salut
[Freixas Bermejo M, Segarra Cantón O] Unitat de Gastroenterologia, Hepatologia, Suport Nutricional i Trasplantaments Hepàtics Pediàtrics, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Riera Soler L] Servei de Radiologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [García Martínez L] Servei de Cirurgia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2025-10-16T07:23:15Z
2025-10-16T07:23:15Z
2025
Crohn disease; Inflammatory bowel disease; Pneumothorax
Malaltia de Crohn; Malaltia inflamatòria intestinal; Pneumotòrax
Enfermedad de Crohn; Enfermedad inflamatoria intestinal; Neumotórax
Introduction: We present the case of a patient with Crohn's disease who experienced recurrent pneumothorax after starting treatment with ustekinumab. Case presentation: A patient with Crohn's disease started an induction regimen with intravenous ustekinumab, and 2 months later he presented a left-sided pneumothorax. It had an atypical evolution that required surgical management. The medication was withdrawn and the pneumothorax resolved completely. One year later, he had a new flare-up of Crohn's disease and ustekinumab therapy was restarted, presenting a new episode of pneumothorax. Conclusion: To our knowledge, this is the first report of recurrent pneumothorax following two separate attempts to initiate ustekinumab.
Article
Published version
English
Crohn, Malaltia de - Tractament; Anticossos monoclonals - Ús terapèutic - Efectes secundaris; Pneumotòrax; DISEASES::Respiratory Tract Diseases::Pleural Diseases::Pneumothorax; DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn Disease; Other subheadings::Other subheadings::Other subheadings::/drug therapy; CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal; Other subheadings::Other subheadings::Other subheadings::/adverse effects; ENFERMEDADES::enfermedades respiratorias::enfermedades pleurales::neumotórax; ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal::enfermedad de Crohn; Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia; COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales; Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
Karger
Case Reports in Gastroenterology;19(1)
https://doi.org/10.1159/000543991
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
Articles científics - HVH [3439]
