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Título:
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Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: incidence and comorbidities of antidepressant initiators
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Autor/a:
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Forns, Joan; Pottegård, Anton; Reinders, Tammo; Poblador-Plou, Beatriz; Morros, Rosa; Brandt, Lena; Cainzos-Achirica, Miguel; Hellfritzsch, Maja; Schink, Tania; Prados-Torres, Alexandra; Giner-Soriano, Maria; Hägg, David; Hallas, Jesper; Cortés, Jordi; Jacquot, Emmanuelle; Deltour, Nicolas; Perez-Gutthann, Susana; Pladevall-Vila, Manel; Reutfors, Johan
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Otros autores:
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[Forns J, Perez-Gutthann S, Pladevall M, Cainzos-Achirica M] Epidemiology, RTI Health Solutions, Barcelona, Spain. [Pottegård A, Hellfritzsch M, Hallas J] Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark. [Reinders T, Schink T] Leibniz Institute for Prevention Research and Epidemiology–BIPS, Bremen, Germany. [Poblador-Plou B, Prados-Torres A] EpiChron Research Group on Chronic Diseases, Aragon Health Sciences Institute (IACS), IIS Aragón, REDISSEC ISCIII, Miguel Servet University Hospital, Zaragoza, Spain. [Morros R, Giner-Soriano M] Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Institut Català de la Salut, Barcelona, Spain. [Brandt L, Reutfors J, Hägg D] Centre for Pharmacoepidemiology, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. [Cortés J] Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya, Barcelona, Spain. [Jacquot E, Deltour N] Pharmacoepidemiology Department, Les Laboratoires Servier, Suresnes, France; IDIAP Jordi Gol |
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Abstract:
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Antidepressants; Comorbidity; Drug utilization study; Europe |
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Abstract:
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Antidepresivos; Comorbilidad; Estudio de utilización de medicamentos; Europa |
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Abstract:
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Antidepressius; Comorbiditat; Estudi d'utilització de medicaments; Europa |
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Abstract:
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Background
We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009–2014 in Denmark, Germany, Spain, and Sweden.
Methods
Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine.
Results
Citalopram was the most prescribed study antidepressant, followed by mirtazapine. Paroxetine and agomelatine were the least prescribed antidepressants. Mirtazapine was widely used among older antidepressant initiators with higher percentages of comorbidities at baseline, and fluoxetine was used among young patients. Citalopram and amitriptyline had the lowest percentage of multiple antidepressant use in the 12 months prior to the current treatment episode, while agomelatine, duloxetine, and venlafaxine had the highest percentage of multiple antidepressant use in the year prior to the current treatment episode.
Limitations
The most important limitations are exposure information based on filled prescriptions, focus on antidepressant initiators only, lack of information on the indication, and heterogeneity of the type of data across data sources.
Conclusions
Results of this study including 4.8 million study antidepressant initiators of study antidepressants suggest that citalopram and mirtazapine are the most commonly prescribed antidepressants. Agomelatine and paroxetine were the least used antidepressants in the participating populations. Mirtazapine was the antidepressant most commonly prescribed among older antidepressant initiators with high percentage of comorbidities at baseline, whereas fluoxetine was commonly used among young patients. |
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Materia(s):
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-Farmacoepidemiologia
-Medicaments - Ús
-Comorbiditat
-Pharmacoepidemiology
-HEALTH CARE::Health Services Administration::Organization and Administration::Pharmacy Administration::Drug Utilization
-HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity
-farmacoepidemiología
-ATENCIÓN DE SALUD::Administración de los Servicios de Salud::Organización y Administración::Administración Farmacéutica::Utilización de Medicamentos
-ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::factores epidemiológicos::comorbilidad |
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Derechos:
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Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Tipo de documento:
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Artículo
Artículo - Versión publicada |
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Editor:
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ScienceDirect
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Compartir:
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