dc.contributor
Institut Català de la Salut
dc.contributor
[Domingo E] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Fisiologia, Escola de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Grignola JC] Pathophysiology Department, School of Medicine, Hospital de Clínicas, Universidad de la República, Avda Italia 2870, PC 11600 Montevideo, Uruguay. [Aguilar R] Cardiology Department, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain. [Messeguer ML] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Roman A] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Ciberes, Instituto de Salud Carlos III, Madrid, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Domingo Ribas, Enric
dc.contributor.author
Aguilar Torres, Rio Jorge
dc.contributor.author
Roman, Antonio
dc.contributor.author
López Meseguer, Manuel
dc.contributor.author
Grignola, Juan
dc.date.accessioned
2025-10-24T10:30:20Z
dc.date.available
2025-10-24T10:30:20Z
dc.date.issued
2021-04-27T11:07:25Z
dc.date.issued
2021-04-27T11:07:25Z
dc.date.issued
2017-05-06
dc.identifier
Domingo E, Grignola JC, Aguilar R, Messeguer ML, Roman A. Pulmonary arterial wall disease in COPD and interstitial lung diseases candidates for lung transplantation. Respir Res. 2017 May 6;18:85.
dc.identifier
https://hdl.handle.net/11351/5911
dc.identifier
10.1186/s12931-017-0568-z
dc.identifier
000400646200001
dc.identifier.uri
https://hdl.handle.net/11351/5911
dc.description.abstract
Malaltia pulmonar obstructiva crònica; Trasplantament de pulmó; Paret arterial pulmonar
dc.description.abstract
Enfermedad pulmonar obstructiva crónica; Trasplante de pulmón; Pared arterial pulmonar
dc.description.abstract
Chronic obstructive pulmonary disease; Lung transplantation; Pulmonary arterial wall
dc.description.abstract
Background
Pulmonary hypertension (PH) associated with lung disease has the worst prognosis of all types of PH. Pulmonary arterial vasculopathy is an early event in the natural history of chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). The present study characterized the alterations in the structure and function of the pulmonary arterial (PA) wall of COPD and ILD candidates for lung transplantation (LTx).
Methods
A cohort of 73 patients, 63 pre-LTx (30 COPD, 33 ILD), and ten controls underwent simultaneous right heart catheterisation and intravascular ultrasound (IVUS). Total pulmonary resistance (TPR), capacitance (Cp), and the TPR-Cp relationship were assessed. PA stiffness and the relative area of wall thickness were estimated as pulse PA pressure/IVUS pulsatility and as [(external sectional area-intimal area)/external sectional area] × 100, respectively.
Results
Twenty-seven percent of patients had pulmonary arterial wedge pressure > 15 mmHg and were not analyzed. PA stiffness and the area of wall thickness were increased in comparison with controls, even in patients without PH (p < 0.05). ILD patients showed a significant higher PA stiffness, and lower Cp beyond mean PA pressure (mPAP) and lower area of wall thickness than COPD patients (p < 0.05). TPR-Cp relationship was shifted downward left for ILD patients.
Conclusions
Significant increase of PA stiffness and area of wall thickness were present even in patients without PH and can make the diagnosis of pulmonary vasculopathy at a preclinical stage in PH-lung disease candidates for LTx. ILD patients showed the worst PA stiffness and Cp with respect to COPD.
dc.description.abstract
Partially support by a grant of Boston Scientific Corporation, USA.
dc.format
application/pdf
dc.relation
Respiratory Research;18
dc.relation
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-017-0568-z
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Pulmons - Malalties obstructives
dc.subject
Hipertensió pulmonar
dc.subject
Pulmons - Trasplantació
dc.subject
DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial
dc.subject
DISEASES::Respiratory Tract Diseases::Lung Diseases::Hypertension, Pulmonary
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Surgical Procedures, Operative::Transplantation::Organ Transplantation::Lung Transplantation
dc.subject
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales
dc.subject
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::hipertensión pulmonar
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::intervenciones quirúrgicas::trasplante::trasplante de órganos::trasplante de pulmón
dc.title
Pulmonary arterial wall disease in COPD and interstitial lung diseases candidates for lung transplantation
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
