Sistema de Salut de Catalunya
Institut Català de la Salut
[Roca N] Servicio de Nefrología Pediátrica, Consorci Hospitalari de Vic, Barcelona, Spain. Universitat de Vic, Barcelona, Spain. [Jatem E, Martín ML, Molina M, Martínez C] Servicio de Nefrología, Hospital Universitario Arnau de Vilanova, Lleida, Spain. Vascular & Renal Translational Research Group, IRBLleida, Spanish Research Network for Renal Diseases (RedInRen.ISCIII), Lleida, Spain. [Muñoz M] Servei de Nefrologia Pediàtrica, Vall d'Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2021-07-15T12:15:06Z
2021-07-15T12:15:06Z
2020
2020-01-17
Biomarcadors; Activació endotelial; Síndrome nefròtica
Biomarcadores; Activación endotelial; Síndrome nefrótico
Biomarkers; Endothelial activation; Nephrotic syndrome
Background Serum levels of soluble urokinase-type plasminogen activator receptor (suPAR) are high in some patients with idiopathic nephrotic syndrome (INS). Given that suPAR constitutes a predictor of vascular disease and has been associated with endothelial dysfunction, we hypothesized that suPAR levels are related to endothelial activation or dysfunction in INS patients. The aims of this study were to evaluate the relationship between serum concentrations of endothelial biomarkers and suPAR in patients with different histological patterns of INS and healthy controls, and to determine the demographic, clinical and biochemical characteristics of INS patients that influence suPAR serum levels. Methods This observational, cross-sectional study included patients with INS, diagnosed with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS) or membranous nephropathy (MN) by renal biopsy. Patient demographic, clinical and biochemical characteristics were recorded and blood samples were obtained at the time of diagnosis. Measurements of suPAR and endothelial molecules via serum levels were performed using Enzyme-Linked ImmunoSorbent Assay kits. Results Patients with nephrotic syndrome (n = 152) caused by FSGS, MCD or MN had increased circulating levels of endothelial markers. suPAR levels positively correlated with age and the serum levels of almost all endothelial markers. Generally, endothelial cell molecules positively correlated with each other. suPAR levels were not associated with the histopathological pattern of INS. Conclusions In patients with INS secondary to FSGS, MCD and NM, circulating levels of suPAR are independent of the primary renal disease, and significantly associated with age, glomerular filtration rate and the levels of various endothelial markers.
C.M. is supported by a Miguel Servet grant, Fondo de investigación sanitaria, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades, CP18/00116. No additional funding was required in the development of the current study
Article
Published version
English
Ronyons - Malalties; Activadors plasminògens; DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Nephrosis::Nephrotic Syndrome; CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::GPI-Linked Proteins::Receptors, Urokinase Plasminogen Activator; ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::nefrosis::síndrome nefrótico; COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::glicoproteínas::glicoproteínas de membranas::proteínas ligadas a GPI::receptores del activador del plasminógeno de tipo urocinasa
Oxford University Press
Clinical Kidney Journal;14(2)
https://academic.oup.com/ckj/article/14/2/543/5709132
info:eu-repo/grantAgreement/ES/PE2013-2016/CP18%2F00116
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
Articles científics - HVH [3440]
