Sistema de Salut de Catalunya
Institut Català de la Salut
[Escolà-Vergé L, Rodríguez-Pardo D, Pigrau C] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, 28029 Madrid, Spain. Study Group on Osteoarticular Infections of the Spanish Society of Clinical Microbiology and Infectious Diseases (GEIO-SEIMC), 28003 Madrid, Spain. [Corona PS] Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, 28029 Madrid, Spain. Study Group on Osteoarticular Infections of the Spanish Society of Clinical Microbiology and Infectious Diseases (GEIO-SEIMC), 28003 Madrid, Spain. Unitat de Cirurgia Sèptica i Reconstructiva, Servei de Cirurgia Ortopèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2021-12-07T13:31:46Z
2021-12-07T13:31:46Z
2021-04
Fong; Infecció articular periprotèsica; Cirurgia d'intercanvi en dues etapes
Hongo; Infección de la articulación periprotésica; Cirugía de recambio en dos etapas
Fungus; Periprosthetic joint infection; Two-stage exchange surgery
Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonable.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Article
Published version
English
Candidiasi - Tractament; Pròtesis - Complicacions; DISEASES::Bacterial Infections and Mycoses::Mycoses::Candidiasis; Other subheadings::Other subheadings::/therapy; DISEASES::Bacterial Infections and Mycoses::Infection::Prosthesis-Related Infections; ENFERMEDADES::infecciones bacterianas y micosis::micosis::candidiasis; Otros calificadores::Otros calificadores::/terapia; ENFERMEDADES::infecciones bacterianas y micosis::infección::infecciones relacionadas con prótesis
MDPI
Antibiotics;10
https://doi.org/10.3390/antibiotics10040458
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - HVH [3440]
