Sistema de Salut de Catalunya
[Madurell J] Centre d'Atenció Primària Hostalric, Institut d'Assistència Sanitària (IAS), Breda-Hostalric, Spain. [Balagué M] Centre d'Atenció Primària, Centre Penitenciari d'Homes, Institut Català de la Salut, Barcelona, Spain. [Gómez M] Atenció Primària de Salut Centre Doctor Josep Torner i Fors, Salut Maresme, Malgrat de Mar, Spain. [Cots J M] Centre d'Atenció Primària La Marina, Universitat de Barcelona, Barcelona, Spain. [Llor C] Centre d'Atenció Primària de Salut Jaume I, Universitat Rovira i Virgili, Tarragona, Spain
Institut d'Assistència Sanitària
2021-12-09T13:01:17Z
2021-12-09T13:01:17Z
2010-03-23
Dolor de garganta; Otitis media aguda; Prescripción de antibióticos
Sore throat; Acute otitis medium; Antibiotic prescription
Mal de gola; Otitis mitjana aguda; Prescripció d'antibiòtics
Background: Acute pharyngitis is one of the most frequent consultations to the general practitioner and in most of the cases an antibiotic is prescribed in primary care in Spain. Bacterial etiology, mainly by group A beta-hemolytic streptococcus (GABHS), accounts for 10-20% of all these infections in adults. The purpose of this study is to assess the impact of rapid antigen detection testing (RADT) to identify GABHS in acute pharyngitis on the utilization of antibiotics in primary care. Methods/design: Multicentric randomized controlled trial in which antibiotic prescription between two groups of patients with acute pharyngitis will be compared. The trial will include two arms, a control and an intervention group in which RADT will be performed. The primary outcome measure will be the proportion of inappropriate antibiotic prescription in each group. Two hundred seventy-six patients are required to detect a reduction in antibiotic prescription from 85% in the control group to 75% in the intervention group with a power of 90% and a level of significance of 5%. Secondary outcome measures will be specific antibiotic treatment, antibiotic resistance rates, secondary effects, days without working, medical visits during the first month and patient satisfaction. Discussion: The implementation of RADT would allow a more rational use of antibiotics and would prevent adverse effects of antibiotics, emergence of antibiotic resistance and the growth of inefficient health expenses.
The study is funded by the Fondo de Investigaciones Sanitarias, theUniversity and Innovation Department of Spain (Reference number:PI061782), and from the Catalan Society of Family Medicine
Article
Published version
English
Faringitis; Estreptococs; Antibiòtics; DISEASES::Respiratory Tract Diseases::Respiratory Tract Infections::Pharyngitis; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Therapeutics::Drug Therapy::Premedication::Antibiotic Prophylaxis; DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Streptococcal Infections; ENFERMEDADES::enfermedades respiratorias::infecciones del tracto respiratorio::faringitis; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::terapéutica::farmacoterapia::premedicación::profilaxis antibiótica; ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones estreptocócicas
BMC
BMC Family Practice;11
https://doi.org/10.1186/1471-2296-11-25
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
