dc.contributor
Institut Català de la Salut
dc.contributor
[Pitsillides L] Department of Surgery and Cancer, South Kensington Campus, Imperial College London, London SW7 2AZ, UK. [Pellino G] Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania Luigi Vanvitelli, 80138 Naples, Italy. Unitat de Cirurgia de Còlon i Recte, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Tekkis P, Kontovounisios C] Department of Surgery and Cancer, South Kensington Campus, Imperial College London, London SW7 2AZ, UK. Department of Colorectal Surgery, Chelsea and Westminster Hospital, London SW10 9NH, UK. Department of Colorectal Surgery, Royal Marsden Hospital, London SW3 6JJ, UK
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Pitsillides, Louise
dc.contributor.author
Tekkis, Paris
dc.contributor.author
Kontovounisios, Christos
dc.contributor.author
Pellino, Gianluca
dc.date.accessioned
2025-10-24T10:33:24Z
dc.date.available
2025-10-24T10:33:24Z
dc.date.issued
2021-12-28T10:08:20Z
dc.date.issued
2021-12-28T10:08:20Z
dc.date.issued
2021-04-25
dc.identifier
Pitsillides L, Pellino G, Tekkis P, Kontovounisios C. The Effect of Perioperative Administration of Probiotics on Colorectal Cancer Surgery Outcomes. Nutrients. 2021 Apr 25;13(5):1451.
dc.identifier
https://hdl.handle.net/11351/6749
dc.identifier
10.3390/nu13051451
dc.identifier
000662347400001
dc.identifier.uri
https://hdl.handle.net/11351/6749
dc.description.abstract
Cirurgia colorectal; Atenció perioperatòria; Probiòtics
dc.description.abstract
Cirugía colorrectal; Atención perioperatoria; Probióticos
dc.description.abstract
Colorectal surgery; Perioperative care; Probiotics
dc.description.abstract
The perioperative care of colorectal cancer (CRC) patients includes antibiotics. Although antibiotics do provide a certain protection against infections, they do not eliminate them completely, and they do carry risks of microbial resistance and disruption of the microbiome. Probiotics can maintain the microbiome’s balance postoperatively by maintaining intestinal mucosal integrity and reducing bacterial translocation (BT). This review aims to assess the role of probiotics in the perioperative management of CRC patients. The outcomes were categorised into: postoperative infectious and non-infectious complications, BT rate analysis, and intestinal permeability assessment. Fifteen randomised controlled trials (RCTs) were included. There was a trend towards lower rates of postoperative infectious and non-infectious complications with probiotics versus placebo. Probiotics reduced BT, maintained intestinal mucosal permeability, and provided a better balance of beneficial to pathogenic microorganisms. Heterogeneity among RCTs was high. Factors that influence the effect of probiotics include the species used, using a combination vs. single species, the duration of administration, and the location of the bowel resection. Although this review provided evidence for how probiotics possibly operate and reported notable evidence that probiotics can lower rates of infections, heterogeneity was observed. In order to corroborate the findings, future RCTs should keep the aforementioned factors constant.
dc.description.abstract
This research received no external funding.
dc.format
application/pdf
dc.relation
Nutrients;13(5)
dc.relation
https://doi.org/10.3390/nu13051451
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Còlon - Càncer - Cirurgia
dc.subject
Recte - Càncer - Cirurgia
dc.subject
Probiòtics - Ús terapèutic - Eficàcia
dc.subject
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
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Other subheadings::Other subheadings::Other subheadings::/surgery
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PHENOMENA AND PROCESSES::Physiological Phenomena::Diet, Food, and Nutrition::Food::Dietary Supplements::Probiotics
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Other subheadings::Other subheadings::Other subheadings::/administration & dosage
dc.subject
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
dc.subject
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::dieta, alimentación y nutrición::alimentos::suplementos dietéticos::probióticos
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/administración & dosificación
dc.title
The Effect of Perioperative Administration of Probiotics on Colorectal Cancer Surgery Outcomes
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
