dc.contributor
Institut Català de la Salut
dc.contributor
[Santos-García D, Naya Rios L, Cores Bartolomé C, García Roca L, Feal Painceiras M, Martínez Miró C] Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain. [de Deus Fonticoba T, Canfield H] Complejo Hospitalario Universitario de Ferrol (CHUF), A Coruña, Spain. [Jesús S, Mir P] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain. Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Aguilar M, Pastor P] Hospital Universitari Mutua de Terrassa, Terrassa , Spain. [Cosgaya M] Hospital Clínic de Barcelona, Barcelona, Spain. [García-Caldentey J] Centro Neurológico Oms, Palma de Mallorca, Spain. [Caballol N] Consorci Sanitari Integral, Hospital Moisés Broggi, Barcelona, Spain. [Legarda I] Hospital Universitari Son Espases, Palma de Mallorca, Spain. [Hernández-Vara J, de Fábregues O] Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Cabo López I, Seijo M] Complexo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain. [López Manzanares L] Hospital Universitario La Princesa, Madrid, Spain. [González Aramburu I] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Hospital Universitario Marqués de Valdecilla, Santander, Spain. [Ávila Rivera MA] Consorci Sanitari Integral, Hospital General de L'Hospitalet, L'Hospitalet de Llobregat, Spain. [Gómez-Mayordomo V] Hospital Universitario Clínico San Carlos, Madrid, Spain. [Nogueira V] Hospital Da Costa, Burela, Lugo, Spain. [Puente V] Hospital del Mar, Barcelona, Spain. [Dotor J] Hospital Universitario Virgen Macarena, Sevilla, Spain. [Borrué C] Hospital Infanta Sofía, Madrid, Spain. [Solano Vila B] Institut d'Assistència Sanitària (IAS), Institut Català de la Salut (ICS), Salt, Spain. [Álvarez Sauco M] Hospital General Universitario de Elche, Elche, Spain. [Vela-Desojo L] Fundación Hospital de Alcorcón, Madrid, Spain. [Escalante S] Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Spain. [Cubo E] Complejo Asistencial Universitario de Burgos, Burgos, Spain. [Carrillo-Padilla F] Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. [Martínez Castrillo JC] Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain. [Sánchez Alonso P] Hospital Universitario Puerta de Hierro, Madrid, Spain. [Alonso Losada MG] Hospital Álvaro Cunqueiro, Complexo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain. [López-Ariztegui N] Complejo Hospitalario de Toledo, Toledo, Spain. [Gastón I] Complejo Hospitalario de Navarra, Pamplona, Spain. [Kulisevsky J] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Hospital de Sant Pau, Barcelona, Spain. [Blázquez Estrada M] Hospital Universitario Central de Asturias, Oviedo, Spain. [Ruiz-Martínez J] Hospital Universitario Donostia, San Sebastián, Spain. [Valero C] Hospital Arnau de Vilanova, València, Spain. [Kurtis M] Hospital Ruber Internacional, Madrid, Spain. [González Ardura J] Hospital de Cabueñes, Gijón, Spain. [Alonso Redondo R] Universitario Lucus Augusti (HULA), Lugo, Spain. [Ordás C] Hospital Rey Juan Carlos, Madrid, Spain. [López Díaz LM] Complexo Hospitalario Universitario de Ourense (CHUO), Ourense, Spain. [McAfee D] University of Maryland School of Medicine, Baltimore, USA. [Martinez-Martin P] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
dc.contributor
Institut d'Assistència Sanitària
dc.contributor.author
de Deus Fonticoba, Teresa
dc.contributor.author
Cores Bartolomé, Carlos
dc.contributor.author
Canfield, Hector
dc.contributor.author
Aguilar, Miquel
dc.contributor.author
Cosgaya, Marina
dc.contributor.author
Ávila Rivera, María A.
dc.contributor.author
Nogueira, Víctor
dc.contributor.author
Solano Vila, Berta
dc.contributor.author
Cubo, Esther
dc.contributor.author
Carrillo Padilla, Francisco
dc.contributor.author
Martinez Castrillo, Juan Carlos
dc.contributor.author
Sánchez Alonso, Pilar
dc.contributor.author
Alonso Losada, Maria G.
dc.contributor.author
López-Ariztegui, Nuria
dc.contributor.author
Gastón, Itziar
dc.contributor.author
Kulisevsky, Jaime
dc.contributor.author
Blázquez Estrada, Marta
dc.contributor.author
Seijo, Manuel
dc.contributor.author
Ruiz-Martinez, Javier
dc.contributor.author
Valero, Caridad
dc.contributor.author
Kurtis, Mónica
dc.contributor.author
de Fabregues-Boixar Nebot, Oriol
dc.contributor.author
González Ardura, Jessica
dc.contributor.author
Alonso Redondo, Ruben
dc.contributor.author
Ordás, Carlos
dc.contributor.author
López Díaz, Luis M.
dc.contributor.author
McAfee, Darrian
dc.contributor.author
Martinez-Martin, Pablo
dc.contributor.author
Mir, Pablo
dc.contributor.author
Garcia-Caldentey, Juan
dc.contributor.author
Legarda, Ines
dc.contributor.author
Cabo López, Iria
dc.contributor.author
Gonzalez-Aramburu, Isabel
dc.contributor.author
Gómez-Mayordomo, Víctor
dc.contributor.author
Pastor, Pau
dc.contributor.author
Lopez Manzanares, Lydia
dc.contributor.author
Puente, Victor
dc.contributor.author
Dotor, Julio
dc.contributor.author
borrue fernandez, carmen
dc.contributor.author
Alvarez Sauco, Maria
dc.contributor.author
Vela-Desojo, Lydia
dc.contributor.author
Escalante Arroyo, Sonia
dc.contributor.author
JESUS MAESTRE, SILVIA
dc.contributor.author
HERNANDEZ-VARA, JORGE
dc.contributor.author
Naya Ríos, Lucía
dc.contributor.author
García Roca, Lucía
dc.contributor.author
Feal, María
dc.contributor.author
Santos García, Diego
dc.contributor.author
MARTINEZ MIRO, CRISTINA
dc.contributor.author
Caballol, Nuria
dc.date.accessioned
2025-10-24T10:28:28Z
dc.date.available
2025-10-24T10:28:28Z
dc.date.issued
2022-01-26T12:02:41Z
dc.date.issued
2022-01-26T12:02:41Z
dc.date.issued
2021-12-17
dc.identifier
Santos García D, Naya Ríos L, de Deus Fonticoba T, Cores Bartolomé C, García Roca L, Feal Painceiras M, et al. Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up. Diagnostics. 2021 Dec 17;11(12):2380.
dc.identifier
https://hdl.handle.net/11351/6907
dc.identifier
10.3390/diagnostics11122380
dc.identifier.uri
https://hdl.handle.net/11351/6907
dc.description.abstract
Malaltia de Parkinson; Fenotip; Tremolor
dc.description.abstract
Enfermedad de Parkinson; Fenotipo; Temblor
dc.description.abstract
Parkinson’s disease; Phenotype; Tremor
dc.description.abstract
Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it. Patients and Methods: PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls. Results: The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716). Conclusions: Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity.
dc.description.abstract
Solano Vila B. has received honoraria for educational presentations and advice service by UCB, Zambon, Teva, Abbvie, Bial
dc.format
application/pdf
dc.relation
Diagnostics;11(12)
dc.relation
https://doi.org/10.3390/diagnostics11122380
dc.rights
Attribution-ShareAlike 4.0 International
dc.rights
http://creativecommons.org/licenses/by-sa/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Parkinson, Malaltia de
dc.subject
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Nervous System Diseases::Central Nervous System Diseases::Movement Disorders::Parkinsonian Disorders::Nervous System Diseases::Parkinson Disease
dc.subject
PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype
dc.subject
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Dyskinesias::Tremor
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::trastornos del movimiento::trastornos parkinsonianos::enfermedades del sistema nervioso::enfermedad de Parkinson
dc.subject
FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::discinesias::temblor
dc.title
Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
