Effectiveness and Safety of a Single-Dose Ivermectin Treatment for Uncomplicated Strongyloidiasis in Immunosuppressed Patients (ImmunoStrong Study): The Study Protocol

Other authors

Institut Català de la Salut

[Salvador F, Molina I] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Spain. [Lucas-Dato A] Internal Medicine Department, Hospital Vega Baja, 03314 Orihuela, Spain. [Roure S] Infectious Diseases Department, North Metropolitan International Health Unit, Germans Trias i Pujol University Hospital, PROSICS North Metropolitan, 08916 Badalona, Spain. [Arsuaga M] Tropical Medicine Unit, Infectious Diseases Department, La Paz-Carlos III University Hospital, 28046 Madrid, Spain. [Pérez-Jacoiste A] Internal Medicine Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain. [García-Rodríguez M] Infectious Diseases Department, Hospital General Universitario de Valencia, 46014 Valencia, Spain

Vall d'Hebron Barcelona Hospital Campus

Publication date

2022-03-11T13:14:36Z

2022-03-11T13:14:36Z

2021-07

Abstract

Strongyloides stercoralis; Immunosupressió; Ivermectina


Strongyloides stercoralis; Inmunosupresión; Ivermectina


Strongyloides stercoralis; Immunosuppression; Ivermectin


Strongyloidiasis affects an estimated 600 million people worldwide, especially in tropical and subtropical areas. Single-dose ivermectin treatment has shown to be effective among immunocompetent patients with uncomplicated strongyloidiasis. Here, we present the protocol of the ImmunoStrong study, a prospective observational study aiming to evaluate the effectiveness and safety of a single-dose ivermectin for treatment of uncomplicated strongyloidiasis in immunosuppressed patients. The secondary objectives are to assess accuracy of molecular techniques for the follow-up of these patients and to determine the population pharmacokinetics of ivermectin. The information retrieved by this study will cover relevant information gaps in the strongyloidiasis management among immunosuppressed patients.


The present work was supported by the 2020 Research Grant from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC).

Document Type

Article


Published version

Language

English

Publisher

MDPI

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Attribution 4.0 International

http://creativecommons.org/licenses/by/4.0/

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