Long-term effects of coronavirus disease 2019 on the cardiovascular system, CV COVID registry: A structured summary of a study protocol

Other authors

Institut Català de la Salut

[Arévalos V, Ortega-Paz L] Department of Cardiology, Clinic Cardiovascular Institute, Hospital Universitari Clinic, Barcelona, Spain. [Fernandez-Rodríguez D] Department of Cardiology, Hospital Universitari Arnau de Vilanova, Lérida, Spain. [Jiménez-Díaz VA] Department of Cardiology, Hospital Universitario de Vigo, Vigo, Spain. [Rius JB] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Campo G] Department of Cardiology, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy

Vall d'Hebron Barcelona Hospital Campus

Publication date

2022-03-22T14:18:27Z

2022-03-22T14:18:27Z

2021-07-29



Abstract

COVID-19; Cardiologia; Pronòstic


COVID-19; Cardiología; Pronóstico


COVID 19; Cardiology; Prognosis


Background Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events, including death from cardiovascular causes. The long-term cardiovascular outcomes of these patients are entirely unknown. We aim to perform a registry of patients who have undergone a diagnostic nasopharyngeal swab for SARS-CoV-2 and to determine their long-term cardiovascular outcomes. Study and design This is a multicenter, observational, retrospective registry to be conducted at 17 centers in Spain and Italy (ClinicalTrials.gov number: NCT04359927). Consecutive patients older than 18 years, who underwent a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV2 in the participating institutions, will be included since March 2020, to August 2020. Patients will be classified into two groups, according to the results of the RT-PCR: COVID-19 positive or negative. The primary outcome will be cardiovascular mortality at 1 year. The secondary outcomes will be acute myocardial infarction, stroke, heart failure hospitalization, pulmonary embolism, and serious cardiac arrhythmias, at 1 year. Outcomes will be compared between the two groups. Events will be adjudicated by an independent clinical event committee. Conclusion The results of this registry will contribute to a better understanding of the long-term cardiovascular implications of the COVID19.


SB. Research grant (COV20/00040) from the Carlos III Institute, Madrid, Spain.

Document Type

Article


Published version

Language

English

Publisher

Public Library of Science

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Attribution 4.0 International

http://creativecommons.org/licenses/by/4.0/

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