dc.contributor
Institut Català de la Salut
dc.contributor
[Vendrell-Serres J] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Psiquiatria, Salut Mental i Addicció, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Psiquiatria i Medicina Forense, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Soto-Angona Ó] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Rodríguez-Urrutia A, Ramos-Quiroga JA] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Psiquiatria, Salut Mental i Addicció, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Psiquiatria i Medicina Forense, Universitat Autònoma de Barcelona, Bellaterra, Spain. Biomedical Network Research Center on Mental Health (CIBERSAM), Barcelona, Spain. [Arteaga-Henríquez G] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Psiquiatria, Salut Mental i Addicció, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Soto Angona, Oscar
dc.contributor.author
Rodríguez Urrutia, Amanda
dc.contributor.author
Arteaga Henriquez, Gara
dc.contributor.author
Vendrell Serres, Júlia
dc.contributor.author
Ramos-Quiroga, Josep Antoni
dc.date.issued
2022-04-06T11:03:44Z
dc.date.issued
2022-04-06T11:03:44Z
dc.identifier
Vendrell-Serres J, Soto-Angona Ó, Rodríguez-Urrutia A, Arteaga-Henríquez G, Ramos-Quiroga JA. Improvement of functional neurological disorder after administration of esketamine nasal spray: a case report. Ther Adv Psychopharmacol. 2021 Jan;11:1–6.
dc.identifier
https://hdl.handle.net/11351/7315
dc.identifier
10.1177/20451253211022187
dc.identifier
000688172400001
dc.description.abstract
Esketamina; Trastorn neurològic funcional; Paràlisi mixta
dc.description.abstract
Esketamina; Trastorno neurológico funcional; Parálisis mixta
dc.description.abstract
Esketamine; Functional neurological disorder; Mixed paralysis
dc.description.abstract
Functional neurological disorder (FND) is a complex neuropsychiatric condition characterized by the presence of neurological symptoms and signs (either motor or sensory) that cannot be explained by any known medical or mental disease. It is frequently presented with psychiatric comorbidities, such as major depression. Its prognosis is poor, with low improvement or recovery rates at 1 year after their onset, and no particular treatment has demonstrated significant efficacy in this regard. Here, we describe the management of a patient affected by treatment-resistant depression (TRD) and FND characterized by mixed paralysis (sensory and motor) in the left arm, and who was successfully treated with esketamine nasal spray, achieving remission in both disorders. The US Food and Drug Administration and the European Medicines Agency recently approved esketamine, the S-enantiomer of ketamine, for treatment of TRD. It is a fast-acting drug that provides a rapid-onset improvement of depressive symptoms. We have presented the first case, to our knowledge, of functional neurological symptoms being successfully treated with esketamine in a patient with comorbid TRD. While the novelty of this data implies a clear need for further research, it is suggested that esketamine might be a useful tool for the treatment of FND, acting through different theorized mechanisms that are in tune with recent advances in knowledge of the etiopathology of FND.
dc.description.abstract
The authors received no financial support for the research, authorship, and/or publication of this article.
dc.format
application/pdf
dc.publisher
SAGE Publications
dc.relation
Therapeutic Advances in Psychopharmacology;11
dc.relation
https://doi.org/10.1177/20451253211022187
dc.rights
Attribution-NonCommercial 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Sistema nerviós - Malalties - Tractament
dc.subject
Aerosolteràpia
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Resistència als medicaments
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DISEASES::Nervous System Diseases
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Other subheadings::Other subheadings::Other subheadings::/drug therapy
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CHEMICALS AND DRUGS::Complex Mixtures::Colloids::Aerosols::Nasal Sprays
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PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Mood Disorders::Depressive Disorder::Depressive Disorder, Treatment-Resistant
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso
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Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
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COMPUESTOS QUÍMICOS Y DROGAS::mezclas complejas::coloides::aerosoles::aerosoles nasales
dc.subject
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del humor::trastorno depresivo::trastorno depresivo resistente al tratamiento
dc.title
Improvement of functional neurological disorder after administration of esketamine nasal spray: a case report
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
